{"id":"W3082173812","doi":"10.1128/jb.00219-20","title":"Novel Functions and Signaling Specificity for the GraS Sensor Kinase of Staphylococcus aureus in Response to Acidic pH","year":2020,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Biology; Staphylococcus aureus; Antimicrobial; Microbiology; Antimicrobial peptides; Proteases; Bacteria; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100253,0.0002966967,0.0001595116,0.0001404338,0.0001233641,0.000270587,0.0001776379,0.0002913237,0.0009528496],"category_scores_gemma":[0.0001217783,0.00008892239,0.0002378175,0.00006347242,0.0001870103,0.0002481343,0.0001670582,0.0003744924,0.0003851113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002483639,"about_ca_system_score_gemma":0.000144259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246908,"about_ca_topic_score_gemma":0.0002631799,"domain_scores_codex":[0.9999342,0.00001060932,0.000004001353,0.00001541088,0.00001697377,0.00001885109],"domain_scores_gemma":[0.9999461,0.000009129856,0.00001199333,0.000004141393,0.000007484804,0.00002105902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008462932,0.000008320233,0.0001395412,0.00001422054,0.000001253538,0.0000598229,0.000008787197,0.00002904105,0.9989687,0.0001818125,0.00001834596,0.0004854117],"study_design_scores_gemma":[0.00005201339,0.0003617994,0.02353789,0.00001464671,0.00001878395,0.002048316,0.0001486389,0.005618896,0.9645404,0.0005749991,0.003060195,0.00002352562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919469,0.001765966,0.003643193,0.0002850021,0.00005626471,0.00001895877,0.0001519315,0.00003323058,0.002098581],"genre_scores_gemma":[0.9960405,0.0004864218,0.001932262,0.0001297931,0.00001889391,0.00001328777,0.0002970339,0.000008135054,0.001073743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009528496,"threshold_uncertainty_score":0.003187537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03698601561555324,"score_gpt":0.2870224370208372,"score_spread":0.2500364214052839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}