{"id":"W3082213712","doi":"10.1101/2020.09.03.281667","title":"Transcriptome-Wide Off-Target Effects of Steric-Blocking Oligonucleotides","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Ontario Genomics","funders":"","keywords":"RNA splicing; Transcriptome; Alternative splicing; In silico; False discovery rate; Computational biology; Biology; Blocking (statistics); Oligonucleotide; Exon skipping; Bioinformatics; Gene; RNA; Gene expression; Exon; Computer science; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001246149,0.0003831456,0.0007104262,0.0002361811,0.0001950032,0.0006571881,0.0001931732,0.0004569464,0.001531753],"category_scores_gemma":[0.001719006,0.0001952364,0.0004775563,0.0001949754,0.0003001476,0.0001827638,0.000213385,0.0005801545,0.0003476718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003928025,"about_ca_system_score_gemma":0.0002490553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006246524,"about_ca_topic_score_gemma":0.0009150159,"domain_scores_codex":[0.9992719,0.0002073667,0.00005060046,0.0001744389,0.0002218561,0.00007383023],"domain_scores_gemma":[0.9987475,0.000852535,0.0001676013,0.00007775723,0.0001055449,0.0000490966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003378697,0.00007124642,0.004007833,0.0001347272,0.00004839752,0.00006265124,0.00002155813,0.005923657,0.9840516,0.0001938841,0.0001299352,0.005016643],"study_design_scores_gemma":[0.00003039256,0.0006888816,0.02529939,0.00001634011,0.0001117765,0.0002005376,0.00005905765,0.05359583,0.917784,0.0004739936,0.001714834,0.00002483935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817888,0.0006018998,0.01416859,0.0001159211,0.00006067019,0.00004584485,0.001493326,0.0003908957,0.001333972],"genre_scores_gemma":[0.9902749,0.000229909,0.006934699,0.0001746886,0.00000949757,0.00004605574,0.001577211,0.00007358865,0.0006794547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001531753,"threshold_uncertainty_score":0.006590366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102086465222852,"score_gpt":0.2262209971258265,"score_spread":0.2160123506035413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}