{"id":"W3082264507","doi":"10.1038/s41588-020-0681-7","title":"Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer","year":2020,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Terry Fox Foundation; Prostate Cancer Canada; Congressionally Directed Medical Research Programs; Princess Margaret Cancer Foundation; National Cancer Institute; U.S. Department of Health and Human Services; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"FOXA1; Biology; Chromatin; Demethylation; Prostate cancer; Cancer; Cancer research; Genetics; DNA methylation; DNA; Breast cancer; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009405627,0.0001233168,0.0002345744,0.00009514992,0.00002341523,0.000007832276,0.0000721397,0.0001754302,0.0001067482],"category_scores_gemma":[0.00009721037,0.00009909833,0.00003804598,0.0006757295,0.00004402007,0.00002872741,0.00003361542,0.000452864,0.000009116635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050996,"about_ca_system_score_gemma":0.0002066861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002552524,"about_ca_topic_score_gemma":0.0000112423,"domain_scores_codex":[0.9989051,0.00003282734,0.0002406961,0.0002340558,0.0003549783,0.0002323381],"domain_scores_gemma":[0.9995022,0.00002937873,0.00009044705,0.0001168948,0.0001380145,0.0001230863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004945473,0.0001373636,0.2727928,0.0005584196,0.0001247753,0.00004233895,0.003331678,0.00001760598,0.6986516,0.000001162137,0.009548511,0.01429916],"study_design_scores_gemma":[0.00396403,0.0006625828,0.04928289,0.0002446282,0.00007348553,0.000002430399,0.000142705,0.00395721,0.9332975,0.0000249274,0.008177211,0.0001703913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764026,0.01645514,0.00000511293,0.005888571,0.00006322971,0.000807206,0.000205253,0.00002598448,0.0001469191],"genre_scores_gemma":[0.9955784,0.002603142,0.0006374175,0.000502674,0.00007066358,0.00003764856,0.0002793396,0.00002491925,0.0002658018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2346459,"threshold_uncertainty_score":0.4041113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013716219593562,"score_gpt":0.3309218012239608,"score_spread":0.3107846390280251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}