{"id":"W3082335528","doi":"10.14785/lymphosign-2020-0008","title":"Report of the Canadian Expert Committee on the management of ADA deficiency","year":2020,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital of Winnipeg; University of Calgary; McGill University Health Centre; Izaak Walton Killam Health Centre; Dalhousie University; Western University; University of Toronto; Child and Family Research Institute; Hospital for Sick Children; University of British Columbia; Memorial University of Newfoundland; McMaster University; McMaster Children's Hospital","funders":"","keywords":"Adenosine deaminase deficiency; Adenosine deaminase; Severe combined immunodeficiency; Immunodeficiency; Hematopoietic stem cell transplantation; Medicine; Enzyme replacement therapy; Genetic enhancement; Immune system; Failure to thrive; Transplantation; Immunology; Pediatrics; Gene; Internal medicine; Biology; Adenosine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004300727,0.0000825759,0.00008665005,0.0000221114,0.0001874014,0.00001650488,0.0005707654,0.00004620924,0.00008100041],"category_scores_gemma":[0.00002937825,0.00004725636,0.0001113214,0.0001380867,0.0001049178,0.000001400831,0.00007131258,0.0001058137,0.000002906773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004501967,"about_ca_system_score_gemma":0.000399946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009834312,"about_ca_topic_score_gemma":0.002171738,"domain_scores_codex":[0.9990194,0.0001018065,0.0002291472,0.0001248653,0.0003268363,0.0001979568],"domain_scores_gemma":[0.9992678,0.000009179706,0.0001378675,0.0003751301,0.00008655684,0.0001234561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001454005,0.0001718118,0.004576485,0.00005380044,0.0005372961,0.0002963929,0.0009412313,0.0007010603,0.8815611,0.001210356,0.09169,0.01680648],"study_design_scores_gemma":[0.0006703995,0.001494293,0.001827462,0.00005546141,0.00001800987,0.0002503349,0.0004591443,0.00006268299,0.9654198,0.0001860059,0.02942672,0.0001297106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807966,0.001463515,0.0002068468,0.01019955,0.0001446102,0.0002353771,0.000009193886,0.000002047042,0.006942303],"genre_scores_gemma":[0.9975472,0.0002233733,0.0001058073,0.001897647,0.00009426503,0.000005207707,0.00000196911,0.0000116505,0.0001128611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08385868,"threshold_uncertainty_score":0.1927059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02972448511040811,"score_gpt":0.278463501167259,"score_spread":0.2487390160568509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}