{"id":"W3082335528","doi":"10.14785/lymphosign-2020-0008","title":"Report of the Canadian Expert Committee on the management of ADA deficiency","year":2020,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital of Winnipeg; University of Calgary; McGill University Health Centre; Izaak Walton Killam Health Centre; Dalhousie University; Western University; University of Toronto; Child and Family Research Institute; Hospital for Sick Children; University of British Columbia; Memorial University of Newfoundland; McMaster University; McMaster Children's Hospital","funders":"","keywords":"Adenosine deaminase deficiency; Adenosine deaminase; Severe combined immunodeficiency; Immunodeficiency; Hematopoietic stem cell transplantation; Medicine; Enzyme replacement therapy; Genetic enhancement; Immune system; Failure to thrive; Transplantation; Immunology; Pediatrics; Gene; Internal medicine; Biology; Adenosine; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01836418,0.001211209,0.001402468,0.002723914,0.005015326,0.004002287,0.005169776,0.0107214,0.01111295],"category_scores_gemma":[0.02822923,0.0007252179,0.001862587,0.002325885,0.002108839,0.00145579,0.002729382,0.01048713,0.005034924],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01971653,"about_ca_system_score_gemma":0.126699,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.4461099,"about_ca_topic_score_gemma":0.5573059,"domain_scores_codex":[0.9867427,0.002089467,0.001296191,0.0007786679,0.006978593,0.002114411],"domain_scores_gemma":[0.936452,0.002300995,0.001806723,0.001020923,0.04763161,0.0107878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002805092,0.00003885195,0.001021919,0.0001635069,0.00001835338,0.0002643541,0.0001087587,0.000204627,0.0003224827,0.001625714,0.9506082,0.04559509],"study_design_scores_gemma":[0.00002568343,0.00001699013,0.002049304,0.000766777,0.0000217351,0.0003555562,0.0001514106,0.0001403908,0.0001439385,0.0006285982,0.9956584,0.00004124317],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.003364148,0.07036943,0.00920839,0.6750332,0.0844462,0.003301437,0.004005141,0.0004043182,0.1498678],"genre_scores_gemma":[0.04699933,0.1129696,0.05823773,0.4326394,0.04833582,0.003488167,0.01634297,0.0007722989,0.2802147],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9802835,"threshold_uncertainty_score":0.8870265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02972448511040811,"score_gpt":0.278463501167259,"score_spread":0.2487390160568509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}