{"id":"W3082353906","doi":"10.1002/mds.28197","title":"The Parkinson's Disease <scp>Genome‐Wide</scp> Association Study Locus Browser","year":2020,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Common Fund; National Institute on Minority Health and Health Disparities; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; European Regional Development Fund; National Center for Advancing Translational Sciences; Medical Research Council; National Institutes of Health; National Human Genome Research Institute; UK Dementia Research Institute; Cardiff University; University of California, San Francisco; Alzheimer's Society; Georgia Clinical and Translational Science Alliance; Lieber Institute for Brain Development; American Heart Association; Broad Institute; U.S. Department of Health and Human Services; COPD Foundation; University of Chicago; Mississippi State Department of Health; Michael J. Fox Foundation for Parkinson's Research; Amgen; Donald W. Reynolds Foundation; Jackson State University; AstraZeneca; Pfizer; Cure Cancer Australia Foundation; Case Western Reserve University; Cleveland Clinic; Llywodraeth Cymru; Sunovion; National Center for Research Resources; Fondation Leducq; NIH Office of the Director; Yale University","keywords":"Genome-wide association study; Genome; Locus (genetics); Genetic association; Genomics; Disease; Genetics; Computational biology; Gene; Biology; Bioinformatics; Medicine; Single-nucleotide polymorphism; Genotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002333501,0.000296127,0.0002837496,0.00004721781,0.0003825946,0.0001012948,0.0001862031,0.00005286096,0.00008158188],"category_scores_gemma":[0.0004786303,0.0002184864,0.0002075551,0.000283778,0.00002743347,0.00009625566,0.0001045593,0.000161523,0.0002227232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003103028,"about_ca_system_score_gemma":0.0001074692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006945846,"about_ca_topic_score_gemma":0.0001115742,"domain_scores_codex":[0.9977071,0.0001133008,0.0003071423,0.000522345,0.0008230492,0.0005270636],"domain_scores_gemma":[0.9986045,0.0001711826,0.0001827644,0.0003900655,0.00007206045,0.0005794709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001520872,0.001816232,0.9738751,0.0000344773,0.0008186717,0.00007920944,0.0007774801,0.00004304591,0.00007670621,0.0001116087,0.01740821,0.004807181],"study_design_scores_gemma":[0.003758776,0.000551605,0.7319846,0.00001052035,0.0004719978,2.127872e-8,0.003261303,0.0001967218,0.00004761452,0.002368897,0.2572531,0.00009492056],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794132,0.001708663,0.00023486,0.01319093,0.0002254311,0.002136939,0.00006216646,0.0001734808,0.002854359],"genre_scores_gemma":[0.9852892,0.0004491756,0.00002361554,0.01131566,0.0001128225,0.0003270055,0.00007329063,0.00005014668,0.002359133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2418906,"threshold_uncertainty_score":0.8909615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158719038488202,"score_gpt":0.2349052929324711,"score_spread":0.2233181025475891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}