{"id":"W3082363863","doi":"10.3389/fneur.2020.00784","title":"Multiple Sclerosis as a Syndrome—Implications for Future Management","year":2020,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Multiple Sclerosis Australia; National Institute of Neurological Disorders and Stroke; Medical Research Council; National Health and Medical Research Council; State Government of Victoria; Australian Government; Strong","keywords":"Multiple sclerosis; Neuroscience; MERTK; Phenocopy; Disease; Immune system; Biology; Computational biology; Medicine; Immunology; Phenotype; Genetics; Gene; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007230825,0.0001321546,0.0002601838,0.0001107998,0.0001123885,0.000007399724,0.0002382103,0.0002351797,0.00003877381],"category_scores_gemma":[0.00004435558,0.0001355671,0.00008695594,0.0001934829,0.00008242767,0.00006598738,0.00007336002,0.0001908018,0.00006805106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000162665,"about_ca_system_score_gemma":0.00001668762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006448262,"about_ca_topic_score_gemma":0.00000407667,"domain_scores_codex":[0.9989763,0.0001023076,0.0002409393,0.0003643059,0.00001598765,0.0003001088],"domain_scores_gemma":[0.9996083,0.0000540316,0.00007712247,0.0002135481,0.00002319055,0.00002385454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.003886762,0.0006946676,0.3034477,0.0002586794,0.0008921403,0.00002927186,0.001685817,0.000473188,0.1269447,0.01672615,0.4166638,0.1282971],"study_design_scores_gemma":[0.00421493,0.0008060426,0.6566743,0.0000104974,0.00006443047,0.0000706155,0.00018867,0.0002170234,0.002597912,0.001869361,0.3330334,0.0002528664],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9223081,0.005190981,0.01835272,0.04788249,0.003650568,0.001612086,0.00008811778,0.0001598697,0.0007550467],"genre_scores_gemma":[0.9938092,0.0003516572,0.00128205,0.003917413,0.00004348301,0.0002569066,0.0001468968,0.00002004516,0.000172388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3532266,"threshold_uncertainty_score":0.5528266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02430382891886136,"score_gpt":0.2203753756991387,"score_spread":0.1960715467802773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}