{"id":"W3082366829","doi":"10.1093/eurheartj/ehaa689","title":"Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to <i>ANGPTL3</i> mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia","year":2020,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Steatosis; Internal medicine; Diabetes mellitus; Triglyceride; Endocrinology; Cholesterol; Drug; Gastroenterology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004396796,0.0003622115,0.0006463482,0.0002076314,0.0001732796,0.0001555489,0.0001093344,0.00004720985,0.00005190856],"category_scores_gemma":[0.000197451,0.000281076,0.00007450303,0.0004287295,0.0001165805,0.0003746742,0.00008917878,0.0005040959,0.00002857562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003311172,"about_ca_system_score_gemma":0.00009735494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003688185,"about_ca_topic_score_gemma":0.00002062289,"domain_scores_codex":[0.9976649,0.0003796255,0.0004961552,0.0004989458,0.0004218732,0.0005385147],"domain_scores_gemma":[0.9982616,0.00004064823,0.0001377071,0.0002680608,0.0001007499,0.001191275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001281878,0.0002491545,0.9699979,0.00008862558,0.00007831231,0.0001335831,0.001827025,0.00001246447,0.02127304,0.000001716274,0.001052231,0.00400407],"study_design_scores_gemma":[0.01107267,0.00263939,0.9746946,0.000308035,0.0001651683,0.0001187197,0.0003598416,0.000143154,0.002601443,0.000001880618,0.007443231,0.0004518357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962678,0.001022598,0.00001039161,0.00160623,0.000133267,0.0007216306,0.00001987602,0.00006630168,0.0001519333],"genre_scores_gemma":[0.9939926,0.0002271673,0.001047456,0.004228686,0.0003241358,0.000004215768,0.0000196305,0.0001095484,0.00004657848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0186716,"threshold_uncertainty_score":0.9999641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234621420681327,"score_gpt":0.2239687632904264,"score_spread":0.2116225490836131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}