{"id":"W3082366829","doi":"10.1093/eurheartj/ehaa689","title":"Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to <i>ANGPTL3</i> mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia","year":2020,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Steatosis; Internal medicine; Diabetes mellitus; Triglyceride; Endocrinology; Cholesterol; Drug; Gastroenterology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003419929,0.0006902221,0.0008690378,0.0002296551,0.0001536314,0.0002303033,0.0003178265,0.0004445337,0.001354451],"category_scores_gemma":[0.0002730794,0.0002493437,0.0003886242,0.0002148504,0.0003255444,0.0002485619,0.0001296062,0.0008438845,0.0002473208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002125375,"about_ca_system_score_gemma":0.0003681566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006089697,"about_ca_topic_score_gemma":0.001965377,"domain_scores_codex":[0.9998569,0.00005420741,0.00001402894,0.00002124861,0.00002296111,0.00003055137],"domain_scores_gemma":[0.9998435,0.00002472266,0.00005743912,0.000006634112,0.000008141512,0.00005962314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2687761,0.01827539,0.01053796,0.001206531,0.001210049,0.0004226535,0.0001891662,0.001065156,0.4991595,0.0001500803,0.001524884,0.1974825],"study_design_scores_gemma":[0.2135796,0.6501709,0.06871697,0.0001000668,0.001242365,0.001557729,0.0001323609,0.001829702,0.05817252,0.0001154426,0.004326153,0.00005629356],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946403,0.003934389,0.000334529,0.00007592361,0.00004440125,0.0001405718,0.0001096171,0.00006762124,0.0006527745],"genre_scores_gemma":[0.9955288,0.002171817,0.0008191615,0.0001422874,0.00006588801,0.0001154154,0.0003352595,0.000007862045,0.0008135933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354451,"threshold_uncertainty_score":0.004531085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01234621420681327,"score_gpt":0.2239687632904264,"score_spread":0.2116225490836131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}