{"id":"W3082375605","doi":"10.1021/acsomega.0c02282","title":"Accessing the Ene–Imine Motif in 1<i>H</i>-Isoindole, Thienopyrrole, and Thienopyridine Building Blocks","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation","keywords":"Isoindole; Imine; Ene reaction; Chemistry; Thienopyridine; Combinatorial chemistry; Nucleophilic addition; Nucleophile; Stereochemistry; Medicinal chemistry; Catalysis; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545364,0.0002500772,0.0003267237,0.00007132137,0.0002459853,0.0001131251,0.0004755703,0.0001327148,0.0001722107],"category_scores_gemma":[0.0001964537,0.0001908581,0.00005332672,0.0003627554,0.0001655678,0.000240215,0.0002905409,0.0004704422,0.00000665955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002077294,"about_ca_system_score_gemma":0.0000293581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005695966,"about_ca_topic_score_gemma":0.000009568917,"domain_scores_codex":[0.9985953,0.0000529116,0.0003394437,0.00043786,0.0001949178,0.0003795622],"domain_scores_gemma":[0.9990153,0.0004379115,0.0001486132,0.0002287576,0.00003414645,0.0001352947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001002943,0.00007617051,0.01209311,0.0001034676,0.00007397991,0.00004469776,0.003120299,0.0001691263,0.9549834,0.0001421781,0.001788346,0.02730491],"study_design_scores_gemma":[0.002073082,0.0000644093,0.01195771,0.0001491757,0.00008800839,0.00003744824,0.001216337,0.005825215,0.9186524,0.0005102396,0.05881663,0.0006093445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824833,0.002464409,0.00004448675,0.008911122,0.00006332316,0.00008808704,0.00001507325,0.00008838459,0.005841817],"genre_scores_gemma":[0.9961485,0.0003015033,0.0004922437,0.002556512,0.0003549509,0.00002021062,0.000007601821,0.00003355408,0.00008487411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05702829,"threshold_uncertainty_score":0.7782967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03012847299501298,"score_gpt":0.2770512302778126,"score_spread":0.2469227572827997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}