{"id":"W3082399821","doi":"10.1038/s41598-020-71788-z","title":"Real-world analyses of therapy discontinuation of checkpoint inhibitors in metastatic melanoma patients","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Toronto; Sunnybrook Health Science Centre; McGill University Health Centre; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"","keywords":"Nivolumab; Ipilimumab; Pembrolizumab; Discontinuation; Medicine; Internal medicine; Oncology; Population; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01252198,0.0004060475,0.001011092,0.001167357,0.0003111734,0.001466512,0.0008826412,0.0008448714,0.001388181],"category_scores_gemma":[0.03453021,0.0005215292,0.003117098,0.001651365,0.0003823283,0.0009353021,0.0009705908,0.001548344,0.0001981181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008504405,"about_ca_system_score_gemma":0.0004585316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003689336,"about_ca_topic_score_gemma":0.002409611,"domain_scores_codex":[0.9890031,0.007267865,0.001026007,0.00152377,0.0006990135,0.0004802783],"domain_scores_gemma":[0.9553016,0.01949343,0.01922017,0.003535415,0.001529738,0.0009196143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002311332,0.00008235947,0.9879689,0.0001436546,0.002391488,0.000154849,0.0001233045,0.00241386,0.0001164982,0.0002161547,0.0006107093,0.003466862],"study_design_scores_gemma":[0.0002118931,0.0009070107,0.9769423,0.00009697917,0.001207724,0.001048084,0.0002614009,0.01616274,0.0002151891,0.0005381043,0.002353848,0.0000546642],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917521,0.002385728,0.001341771,0.0002904601,0.00002790956,0.00005635214,0.003516297,0.00001905542,0.0006104214],"genre_scores_gemma":[0.9963069,0.0003014551,0.0003834966,0.00009598125,0.00003704842,0.00005060036,0.00270421,0.000007955224,0.0001123899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01252198,"threshold_uncertainty_score":0.06622338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05575432762508323,"score_gpt":0.3356405443520768,"score_spread":0.2798862167269935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}