{"id":"W3082402172","doi":"10.1080/19382014.2020.1802183","title":"The role of α-ketoglutarate and the hypoxia sensing pathway in the regulation of pancreatic β-cell function","year":2020,"lang":"en","type":"review","venue":"Islets","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Metabolite; Secretion; Biology; Cytosol; Pancreatic islets; Insulin; Metabolomics; Hypoxia-inducible factors; Mitochondrion; Cell biology; Biochemistry; Islet; Endocrinology; Enzyme; Bioinformatics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007974693,0.0001872186,0.0009432,0.00005928184,0.00007451016,0.00001801927,0.00008205927,0.0001137759,0.00001170157],"category_scores_gemma":[0.0003688771,0.00006983658,0.0002009634,0.0003101331,0.0001946164,0.00002459977,0.00002761162,0.0002451086,0.0000103067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002485218,"about_ca_system_score_gemma":0.0001245173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004023539,"about_ca_topic_score_gemma":0.000002251187,"domain_scores_codex":[0.9983711,0.0005263724,0.0005447704,0.0001729474,0.0002566797,0.0001280823],"domain_scores_gemma":[0.9975547,0.001547274,0.0004399654,0.0003726966,0.00005650579,0.00002889929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002051581,0.00003025647,0.00001816084,0.002712119,0.0001207727,0.000002572582,0.0004688187,0.000001294443,0.0005811169,0.0008331956,0.000138404,0.9948881],"study_design_scores_gemma":[0.001213799,0.0001704411,0.0003181228,0.003758237,0.001435808,0.00003722683,0.000458184,0.0007236361,0.0002065995,0.001122632,0.9904498,0.0001054597],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003174982,0.9887818,0.00001645925,0.0002893082,0.0001244444,0.0009409878,0.000007171775,0.00001103598,0.006653792],"genre_scores_gemma":[0.07320251,0.9260998,0.00003911416,0.0001464453,0.000143055,0.00002385905,0.00002496752,0.00002226201,0.0002979396],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9947827,"threshold_uncertainty_score":0.2847853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805360048916573,"score_gpt":0.2455268358191866,"score_spread":0.2274732353300208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}