{"id":"W3082402342","doi":"10.1007/978-1-0716-0771-8_7","title":"Degradation of Toxic RNA in Myotonic Dystrophy Using Gapmer Antisense Oligonucleotides","year":2020,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"","keywords":"Myotonic dystrophy; RNase P; RNA; RNase H; Biology; Nuclease; Antisense RNA; Trinucleotide repeat expansion; Myotonia; Gene; Oligonucleotide; Genetics; Cell biology; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004790104,0.001164883,0.001057931,0.001132741,0.0001569316,0.0005277487,0.0005644769,0.0007451086,0.001519244],"category_scores_gemma":[0.0002860002,0.0002884582,0.0003304191,0.0008239834,0.0003887128,0.0006138512,0.0004036227,0.00125906,0.001905296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004787069,"about_ca_system_score_gemma":0.0004798092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004734462,"about_ca_topic_score_gemma":0.000680509,"domain_scores_codex":[0.9998903,0.00001276663,0.0000161367,0.00002394723,0.00004380808,0.00001302305],"domain_scores_gemma":[0.9998865,0.00005379895,0.00002078721,0.000004361459,0.00002473071,0.000009933979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001529456,0.00009154025,0.0001032768,0.009769733,0.00005389308,0.000212926,0.00003703653,0.0005737726,0.02903982,0.003751931,0.0120046,0.9442085],"study_design_scores_gemma":[0.00008165128,0.0003881118,0.001083115,0.002006235,0.0002009438,0.002047355,0.00004106926,0.0003656205,0.02485768,0.0031758,0.9657019,0.00005041291],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004554017,0.996945,0.0009322314,0.0001143637,0.0002030705,0.000008502533,0.00001928232,0.00002081924,0.00130134],"genre_scores_gemma":[0.00200464,0.9952501,0.000717808,0.0001516984,0.0001645062,0.00001983297,0.00006692097,0.000004492131,0.001620069],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001519244,"threshold_uncertainty_score":0.005082369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1243174793214595,"score_gpt":0.4583377042524734,"score_spread":0.3340202249310139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}