{"id":"W3082451282","doi":"10.1186/s13229-020-00373-y","title":"Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms","year":2020,"lang":"en","type":"article","venue":"Molecular Autism","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, Keio University; Japan Society for the Promotion of Science; Keio University; Hospital for Special Surgery; RIKEN; University of Tokyo; Japan Agency for Medical Research and Development; Universität Basel; University of British Columbia; University of Pennsylvania","keywords":"Neuroligin; Biology; Phenotype; Gene; Autism; Missense mutation; Neurexin; Genetics; Induced pluripotent stem cell; Human genetics; Medicine; Embryonic stem cell; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003607946,0.0005911461,0.0007633817,0.0002141869,0.000231168,0.0001170627,0.001376263,0.000372919,0.00030378],"category_scores_gemma":[0.0008458105,0.000669975,0.0003733754,0.001545589,0.0002620337,0.0002693166,0.0007544385,0.0009668487,0.0002119838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001500944,"about_ca_system_score_gemma":0.0003003458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002798938,"about_ca_topic_score_gemma":0.000005285835,"domain_scores_codex":[0.9939324,0.001108409,0.0005919507,0.001496666,0.001545163,0.001325433],"domain_scores_gemma":[0.9979257,0.0001710234,0.0003927555,0.0009130342,0.00001838094,0.0005791163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006002752,0.0004748059,0.00001671206,0.00003804811,0.00007584503,0.001163652,0.0002247803,0.0002209588,0.9459135,0.05103013,0.0004083581,0.0003731947],"study_design_scores_gemma":[0.001948065,0.0008056118,0.004961725,0.00002623224,0.00009356148,0.00007671664,0.000005233785,0.01661756,0.9391204,0.03524125,0.0003474981,0.0007562012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8397596,0.0002957216,0.1255442,0.03071086,0.0002033268,0.001202693,0.000316682,0.0005718778,0.00139504],"genre_scores_gemma":[0.9962415,0.00004206742,0.0001977304,0.003125213,0.000003232521,0.00006443492,0.0000189879,0.0001691956,0.0001377105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1564818,"threshold_uncertainty_score":0.9995751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597181077194916,"score_gpt":0.2563914155517044,"score_spread":0.2404196047797553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}