{"id":"W3082451282","doi":"10.1186/s13229-020-00373-y","title":"Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms","year":2020,"lang":"en","type":"article","venue":"Molecular Autism","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"School of Medicine, Keio University; Japan Society for the Promotion of Science; Keio University; Hospital for Special Surgery; RIKEN; University of Tokyo; Japan Agency for Medical Research and Development; Universität Basel; University of British Columbia; University of Pennsylvania","keywords":"Neuroligin; Biology; Phenotype; Gene; Autism; Missense mutation; Neurexin; Genetics; Induced pluripotent stem cell; Human genetics; Medicine; Embryonic stem cell; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288343,0.0005929498,0.0001862286,0.0003494647,0.0001120662,0.0001484106,0.0001851398,0.000259694,0.0009650182],"category_scores_gemma":[0.0001434332,0.0001014552,0.0002649071,0.0001124935,0.0003679861,0.0001405676,0.0003256137,0.0002316665,0.0001477815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000255881,"about_ca_system_score_gemma":0.0001443964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006118848,"about_ca_topic_score_gemma":0.0009139669,"domain_scores_codex":[0.9998806,0.0000204564,0.00002236435,0.00002720813,0.00003351033,0.00001584092],"domain_scores_gemma":[0.9999034,0.00001506206,0.00005047585,0.000008099042,0.000007891362,0.00001515041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001314965,0.00001318831,0.002241699,0.00004962724,0.00002667382,0.000487154,0.00001647717,0.00006566432,0.995843,0.00006489423,0.0000215923,0.001038485],"study_design_scores_gemma":[0.0000448809,0.0006316857,0.1057359,0.00002349734,0.0001476231,0.007404311,0.0001137108,0.0008987161,0.8827749,0.0002280943,0.001983696,0.0000129767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977355,0.0008509579,0.0007498821,0.00003741022,0.00000608605,0.00001164405,0.0001474366,0.00002515472,0.000436025],"genre_scores_gemma":[0.9980002,0.0006012193,0.0008019331,0.00002215403,0.000002493336,0.00001720709,0.0001982573,0.000008616514,0.0003478831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009650182,"threshold_uncertainty_score":0.003228366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01597181077194916,"score_gpt":0.2563914155517044,"score_spread":0.2404196047797553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}