{"id":"W3082501668","doi":"10.1158/1538-7445.am2020-ct273","title":"Abstract CT273: Phase 2 trial of dianhydrogalactitol (VAL-083) in patients with newly diagnosed MGMT-unmethylated glioblastoma","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada)","funders":"","keywords":"Temozolomide; Tolerability; Medicine; Radiosensitizer; Oncology; Regimen; Radiation therapy; Internal medicine; Cancer research; Cancer; Methyltransferase; Chemoradiotherapy; DNA repair; Biology; Adverse effect; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007027186,0.001697726,0.001501705,0.0004341061,0.0003758949,0.0009079069,0.0009482956,0.001024293,0.003941534],"category_scores_gemma":[0.0004256632,0.0004996403,0.0009745711,0.0004556337,0.0008089418,0.0006350309,0.0003845776,0.003312448,0.0009923805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001307103,"about_ca_system_score_gemma":0.002087591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00302682,"about_ca_topic_score_gemma":0.00695202,"domain_scores_codex":[0.9998122,0.00007053634,0.000007864992,0.00003518679,0.00001803256,0.000056278],"domain_scores_gemma":[0.9996506,0.0000284104,0.00004314558,0.00002073606,0.00002348271,0.0002336536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7324402,0.05439682,0.004679664,0.001261999,0.001652174,0.0005858188,0.0003614126,0.004484579,0.08966435,0.0005533746,0.01121708,0.09870251],"study_design_scores_gemma":[0.4641234,0.5117317,0.009388641,0.00006812019,0.0004274302,0.0003567,0.00009459626,0.001891491,0.00732388,0.0002692672,0.004276537,0.00004826043],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988868,0.00284386,0.000463426,0.0006855755,0.0001806477,0.00242658,0.001910583,0.0001830074,0.002438313],"genre_scores_gemma":[0.9835324,0.002818964,0.001042719,0.001152449,0.0001478924,0.002523986,0.003802445,0.00005008361,0.004929041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003941534,"threshold_uncertainty_score":0.01318574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05428933571141433,"score_gpt":0.3911389374430134,"score_spread":0.3368496017315991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}