{"id":"W3082568883","doi":"10.1055/s-0040-1715790","title":"Mutations in SARS-CoV-2 Leading to Antigenic Variations in Spike Protein: A Challenge in Vaccine Development","year":2020,"lang":"en","type":"article","venue":"Journal of Laboratory Physicians","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Antigenicity; Mutation; Biology; Epitope; Genetics; Spike (software development); Genome; Heptad repeat; Coronavirus; Virology; Spike Protein; Sequence analysis; Gene; Peptide sequence; Antigen; Coronavirus disease 2019 (COVID-19); Medicine; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00116721,0.0002586843,0.0004602565,0.000251635,0.0001348015,0.0006877187,0.0002882784,0.0005670654,0.0009216918],"category_scores_gemma":[0.0006086395,0.0001032288,0.0003255721,0.0003290194,0.0001975288,0.0005797565,0.0002353644,0.0006187677,0.0002654524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002868699,"about_ca_system_score_gemma":0.0006062149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004249486,"about_ca_topic_score_gemma":0.0006414604,"domain_scores_codex":[0.9997876,0.00007435367,0.0000214593,0.00003850739,0.00004914604,0.0000289564],"domain_scores_gemma":[0.9997594,0.00006568502,0.00005590039,0.00001406319,0.00005461827,0.00005044836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001567253,0.000948957,0.1300749,0.00201244,0.0002874129,0.003484269,0.0006445056,0.007843476,0.5065139,0.007165187,0.009196036,0.3302615],"study_design_scores_gemma":[0.0006313028,0.0110946,0.4421841,0.002623129,0.001200349,0.01800992,0.00617697,0.061203,0.1782448,0.02789175,0.2504841,0.0002559078],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9170988,0.06328671,0.008305913,0.007952108,0.0003517872,0.0001028671,0.0006900924,0.0001025898,0.002109077],"genre_scores_gemma":[0.9610581,0.02182082,0.01337052,0.0009512105,0.0002586367,0.00004795394,0.001588578,0.00002406389,0.0008800344],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00116721,"threshold_uncertainty_score":0.006172836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05377647455450612,"score_gpt":0.351442778721005,"score_spread":0.2976663041664989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}