{"id":"W3082573938","doi":"10.3390/molecules25174025","title":"Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Austrian Science Fund; TU Graz, Internationale Beziehungen und Mobilitätsprogramme","keywords":"Chemistry; Moiety; Glycoside hydrolase; Stereochemistry; Enzyme; Cyclopentane; Deoxygenation; Galactosidases; Biochemistry; Structure–activity relationship; In vitro; Beta-galactosidase; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008901132,0.0002098045,0.0004801859,0.0001195221,0.0001755408,0.0000206215,0.0001686739,0.00007823919,0.0001538652],"category_scores_gemma":[0.000473154,0.0001487621,0.00008916928,0.0003880035,0.0004166896,0.0001181774,0.0002442072,0.0002013361,0.000004563666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004129197,"about_ca_system_score_gemma":0.00008773067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003025128,"about_ca_topic_score_gemma":0.00005772258,"domain_scores_codex":[0.9984995,0.0001348851,0.0003147679,0.0003421306,0.000504196,0.0002045928],"domain_scores_gemma":[0.9990588,0.0001763131,0.0001760854,0.0002469042,0.0001890436,0.0001528833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006209036,0.0001726639,0.002035348,0.0003056038,0.0001991133,0.00005826977,0.004208059,0.000006329898,0.9848933,0.003925925,0.00002119481,0.00355335],"study_design_scores_gemma":[0.004552972,0.001344839,0.07037856,0.000256638,0.0002722151,0.00002562711,0.002025469,0.002099191,0.9165331,0.001443285,0.0007483114,0.0003197942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921811,0.002032669,0.002771684,0.001673099,0.00002669809,0.0005077401,0.000005845789,0.0000381032,0.0007631228],"genre_scores_gemma":[0.999037,0.0001315587,0.0004205205,0.0001982331,0.00004355751,0.00003527803,0.00003328954,0.00002928764,0.00007122242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06836014,"threshold_uncertainty_score":0.6066341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03159848193960176,"score_gpt":0.2868907687531634,"score_spread":0.2552922868135616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}