{"id":"W3082573938","doi":"10.3390/molecules25174025","title":"Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Biotechnology and Biological Sciences Research Council; Austrian Science Fund; TU Graz, Internationale Beziehungen und Mobilitätsprogramme","keywords":"Chemistry; Moiety; Glycoside hydrolase; Stereochemistry; Enzyme; Cyclopentane; Deoxygenation; Galactosidases; Biochemistry; Structure–activity relationship; In vitro; Beta-galactosidase; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008971355,0.0002409335,0.000122356,0.00007253552,0.00006947068,0.0001503307,0.0001604541,0.0001704479,0.001001528],"category_scores_gemma":[0.00005495359,0.00005695454,0.0001186556,0.00004777413,0.0002007245,0.0001987421,0.0001132474,0.0002693004,0.0001231416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066048,"about_ca_system_score_gemma":0.0002166888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005624174,"about_ca_topic_score_gemma":0.0006384206,"domain_scores_codex":[0.999977,0.000004859878,0.000001623161,0.000003336105,0.000003614532,0.000009519889],"domain_scores_gemma":[0.9999822,0.000003551579,0.000004982374,0.000001959011,0.000002542373,0.000004764877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003672905,0.00006362476,0.000217037,0.0001026318,0.000007153377,0.0002785335,0.0000500972,0.0007023393,0.9925569,0.001807642,0.00007059133,0.003776207],"study_design_scores_gemma":[0.00008541011,0.001264909,0.00132311,0.00001285004,0.00002077931,0.0004235741,0.0000466094,0.001580816,0.989922,0.0003179259,0.004988468,0.00001359898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909459,0.002412094,0.002590219,0.0001689708,0.00002170935,0.00004386514,0.0001424423,0.000039865,0.003634854],"genre_scores_gemma":[0.9962963,0.001507309,0.001318172,0.00005091296,0.000004381521,0.00001466846,0.00007655853,0.000003063562,0.0007286435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001528,"threshold_uncertainty_score":0.003350496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03159848193960176,"score_gpt":0.2868907687531634,"score_spread":0.2552922868135616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}