{"id":"W3082632815","doi":"10.1101/2020.08.31.274589","title":"Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; BC Children's Hospital; University of British Columbia; McGill University; McGill Genome Centre","funders":"New South Wales Government; Helmut Horten Stiftung; Fonds de Recherche en Santé Respiratoire; National Institute of Allergy and Infectious Diseases; Medical Research Council; Université Paris Descartes; Institut National de la Santé et de la Recherche Médicale; National Center for Advancing Translational Sciences; Agence Nationale de la Recherche; National Science Foundation; Stony Wold-Herbert Fund; St. Giles Foundation; Genome Canada; Qatar National Research Fund; Fondation pour la Recherche Médicale; Immune Deficiency Foundation; Fonds National de la Recherche Luxembourg; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Health and Medical Research Council; Sidra Medicine; Brigham and Women's Hospital","keywords":"Immunology; Innate immune system; Acquired immune system; Biology; Immunity; Antigen; Interferon gamma; Interferon; Cytokine; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141384,0.0002340242,0.0001907821,0.0001581965,0.0001934886,0.0003022896,0.0001902694,0.0003767348,0.001864498],"category_scores_gemma":[0.0002635831,0.00007334802,0.0001105987,0.00007481626,0.0002446661,0.0001776438,0.0001636197,0.0003122095,0.0004149905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021948,"about_ca_system_score_gemma":0.000126436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002543462,"about_ca_topic_score_gemma":0.0001885129,"domain_scores_codex":[0.9998933,0.00001981965,0.00001189929,0.00002911642,0.00001903422,0.00002672681],"domain_scores_gemma":[0.9999225,0.00001771335,0.00001872718,0.000007621294,0.00001107047,0.00002239668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005739066,0.00004864412,0.03224316,0.00007586204,0.00001879577,0.004711618,0.000207432,0.0002732843,0.9485752,0.001063215,0.000462325,0.01174663],"study_design_scores_gemma":[0.0001063744,0.0008069315,0.06752069,0.00008546314,0.0001248067,0.07452764,0.0005497858,0.00358052,0.8247359,0.00268842,0.02525105,0.00002251326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948919,0.001452506,0.0009075609,0.0001641949,0.00002045504,0.00000960414,0.0001656627,0.0000464517,0.002341817],"genre_scores_gemma":[0.9982633,0.0002090573,0.0005123996,0.00006307409,0.00001102114,0.00000602276,0.0001498782,0.000005775622,0.0007794745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001864498,"threshold_uncertainty_score":0.006237328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802637884200455,"score_gpt":0.2201352522302821,"score_spread":0.2021088733882775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}