{"id":"W3082645374","doi":"10.1101/2020.08.31.274894","title":"UHRF1 suppresses viral mimicry through both DNA methylation-dependent and -independent mechanisms","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; University of British Columbia","funders":"Medical Research Council; National Institutes of Health; Royal Society","keywords":"DNA methylation; Biology; Gene knockdown; Epigenetics; Gene silencing; Innate immune system; Interferon; Methylation; Cell biology; Cancer research; Molecular biology; Immune system; Cell culture; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169971,0.0003902183,0.000299881,0.0002006692,0.0001421709,0.0002439938,0.0003231239,0.0003246775,0.001497338],"category_scores_gemma":[0.0001433807,0.0001425987,0.0003487834,0.0001049271,0.0002651658,0.0001536781,0.0002263832,0.0005703652,0.0003889427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003059833,"about_ca_system_score_gemma":0.000144254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006339735,"about_ca_topic_score_gemma":0.0009680317,"domain_scores_codex":[0.9998034,0.00003126633,0.00001806347,0.00003985378,0.00005753517,0.00004984636],"domain_scores_gemma":[0.9998295,0.00003587131,0.00004966967,0.00003480356,0.00001686742,0.0000331688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003697701,0.000008611965,0.00005174393,0.00001024358,0.000002830812,0.00000890811,0.000003989725,0.00002440931,0.9995189,0.00003021279,0.00001777991,0.0002854754],"study_design_scores_gemma":[0.000005969382,0.0001604855,0.001248595,0.000001594177,0.000005834038,0.00006411958,0.000006944418,0.0003617252,0.9973776,0.00001284521,0.0007521384,0.000002175622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935963,0.001428743,0.00293477,0.00009239993,0.00003079133,0.0000288768,0.0005343551,0.0001882795,0.001165444],"genre_scores_gemma":[0.9960026,0.0003351633,0.001139111,0.00003291372,0.000007654504,0.00002272239,0.0005412959,0.00002546696,0.001893063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497338,"threshold_uncertainty_score":0.005009055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01488416774453848,"score_gpt":0.2352572029190724,"score_spread":0.2203730351745339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}