{"id":"W3082651101","doi":"10.1021/acs.jnatprod.0c00621","title":"Metabolomic Comparison and Assessment of Co-cultivation and a Heat-Killed Inducer Strategy in Activation of Cryptic Biosynthetic Pathways","year":2020,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"University of Prince Edward Island; Atlantic Canada Opportunities Agency; Canada Research Chairs; Natural Sciences and Engineering Research Council of Canada; Fondation Jean-Louis Lévesque; Canada Foundation for Innovation; Innovation PEI","keywords":"Inducer; Metabolomics; Biology; Natural product; Metabolic pathway; Biochemistry; Biosynthesis; Metabolism; Gene; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003512395,0.0004752013,0.0003800749,0.0004996543,0.0001484586,0.0003438157,0.0001668291,0.0002997306,0.0004757212],"category_scores_gemma":[0.0004572416,0.0001254004,0.0003118339,0.0005927653,0.000197525,0.0003216947,0.0003443808,0.0004178789,0.0001747867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810966,"about_ca_system_score_gemma":0.0002119981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000393117,"about_ca_topic_score_gemma":0.0006994248,"domain_scores_codex":[0.9996412,0.00005929628,0.00002536771,0.00009509992,0.000129646,0.00004936557],"domain_scores_gemma":[0.9997094,0.0000570684,0.00007115639,0.00003407183,0.00008779522,0.00004042331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009046948,0.00001885431,0.000340061,0.00002344721,0.000004365172,0.00001279652,0.000009588805,0.00002930424,0.9984298,0.000008620075,0.000007544923,0.001025024],"study_design_scores_gemma":[0.000006286285,0.0004070208,0.01200705,0.000006374388,0.00003650434,0.00007325882,0.00004454068,0.000701129,0.9859097,0.0000242045,0.0007754432,0.000008427644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857926,0.001510844,0.00961394,0.00007823922,0.00004414071,0.0001233027,0.001556243,0.000103618,0.001176986],"genre_scores_gemma":[0.9784379,0.001229584,0.0158166,0.0000860421,0.00002101749,0.0001932922,0.00235744,0.00004906989,0.001809092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004996543,"threshold_uncertainty_score":0.001857519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04627424702196815,"score_gpt":0.3154410315979007,"score_spread":0.2691667845759325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}