{"id":"W3082654117","doi":"10.1021/acs.molpharmaceut.0c00767","title":"Dual-Location Dual-Acid/Glutathione-Degradable Cationic Micelleplexes through Hydrophobic Modification for Enhanced Gene Silencing","year":2020,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Nanocarriers; Atom-transfer radical-polymerization; Nucleic acid; Combinatorial chemistry; Amphiphile; Cationic polymerization; Gene delivery; Copolymer; Biophysics; Hydrophobic effect; Biochemistry; Drug delivery; Transfection; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000128471,0.0002657475,0.0001978063,0.00003588948,0.0001747383,0.00005673422,0.000204203,0.0001693155,0.00001855044],"category_scores_gemma":[0.00007688023,0.0002966869,0.0001427359,0.0002331691,0.00005893219,0.00002014426,0.00008351534,0.0001304067,0.00005414605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004214618,"about_ca_system_score_gemma":0.0001622469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001856096,"about_ca_topic_score_gemma":0.000004438301,"domain_scores_codex":[0.9983855,0.0000737418,0.0003762023,0.0006079873,0.000198962,0.0003576368],"domain_scores_gemma":[0.9990013,0.00001284491,0.0001769118,0.000367346,0.0003111809,0.0001304133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001265365,0.00006184872,0.000005758168,0.00007395185,0.00009096275,0.00000387854,0.0005113416,0.005516008,0.9918878,0.00008964939,0.000743743,0.0008885103],"study_design_scores_gemma":[0.0008234864,0.000258813,0.000008151361,0.00001456516,0.0001024711,0.00001044589,0.0001633581,0.01180206,0.9775872,0.0001593631,0.008729075,0.0003410421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.728137,0.003048832,0.2669132,0.000920215,0.0001985704,0.0005128982,0.00003602814,0.00004242303,0.000190874],"genre_scores_gemma":[0.9891971,0.0009909401,0.005692982,0.002744702,0.0003006733,0.0001602461,0.0006715749,0.00005966504,0.0001820649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2612202,"threshold_uncertainty_score":0.9999485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04719829635624757,"score_gpt":0.3180596195770795,"score_spread":0.2708613232208319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}