{"id":"W3082654117","doi":"10.1021/acs.molpharmaceut.0c00767","title":"Dual-Location Dual-Acid/Glutathione-Degradable Cationic Micelleplexes through Hydrophobic Modification for Enhanced Gene Silencing","year":2020,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Nanocarriers; Atom-transfer radical-polymerization; Nucleic acid; Combinatorial chemistry; Amphiphile; Cationic polymerization; Gene delivery; Copolymer; Biophysics; Hydrophobic effect; Biochemistry; Drug delivery; Transfection; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002697341,0.0004812651,0.0002186978,0.0001882673,0.00009968334,0.0002383889,0.0002009405,0.0003777245,0.0007854024],"category_scores_gemma":[0.0001506843,0.0001667803,0.0002007728,0.0001053373,0.0003123015,0.0003286231,0.0002523075,0.0004556826,0.000273276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003088323,"about_ca_system_score_gemma":0.0002828797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002163451,"about_ca_topic_score_gemma":0.000413295,"domain_scores_codex":[0.9999059,0.00001658364,0.000006693293,0.00002769524,0.00002749854,0.00001553515],"domain_scores_gemma":[0.999929,0.00001594045,0.00002441194,0.000006877297,0.000008500934,0.00001537796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000072271,0.000006164276,0.00001156022,0.00001384645,0.000001487659,0.000008593163,0.000005539825,0.00005071275,0.9991893,0.0001015829,0.00001007004,0.0005938765],"study_design_scores_gemma":[0.000006688653,0.00007046569,0.00008343329,9.705865e-7,0.000003602065,0.00003296125,0.000001832593,0.0004824003,0.9985269,0.0000186724,0.0007697903,0.000002315574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599136,0.002596376,0.03494376,0.000256059,0.00004779312,0.0001593063,0.0001371048,0.0002278578,0.00171805],"genre_scores_gemma":[0.9749566,0.001298429,0.0200291,0.0001076874,0.0000167894,0.00007834248,0.0001245274,0.00003590613,0.003352663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007854024,"threshold_uncertainty_score":0.002627432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04719829635624757,"score_gpt":0.3180596195770795,"score_spread":0.2708613232208319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}