{"id":"W3082658746","doi":"10.2217/fon-2020-0740","title":"Sequential Afatinib and Osimertinib in Patients with <i>EGFR</i> Mutation-Positive Non-Small-Cell Lung Cancer: Final Analysis of the GioTag Study","year":2020,"lang":"en","type":"article","venue":"Future Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Boehringer Ingelheim","keywords":"Afatinib; Osimertinib; Medicine; Lung cancer; Internal medicine; Oncology; T790M; Clinical trial; Cancer; Adenocarcinoma; Erlotinib; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004487096,0.0001274778,0.0004024151,0.00009041099,0.00006410906,0.000006023568,0.00006270648,0.00006696203,0.00006690063],"category_scores_gemma":[0.000009559428,0.00007948541,0.00006339502,0.0007218148,0.00005332015,0.00003367054,0.00003582297,0.0001536122,5.761471e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681992,"about_ca_system_score_gemma":0.0003794078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005228427,"about_ca_topic_score_gemma":0.001531869,"domain_scores_codex":[0.9991128,0.00008571818,0.0002435068,0.0002588398,0.0001603267,0.0001388437],"domain_scores_gemma":[0.9994278,0.00004985617,0.0001847455,0.000125375,0.0001357461,0.00007646895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007811188,0.0008855312,0.9796025,0.00004058264,0.001720887,0.00003227924,0.01437947,0.0003544364,0.00008736172,0.000008081589,0.0002275642,0.001880239],"study_design_scores_gemma":[0.009511874,0.002129287,0.9781771,0.00002720027,0.006860887,0.00000105079,0.002196195,0.0005187364,0.0001918533,7.467892e-7,0.0003047362,0.00008037357],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946353,0.0001987892,0.00003892967,0.00269572,0.0001289135,0.001251358,0.00009448544,0.000007863936,0.0009486511],"genre_scores_gemma":[0.9982992,0.00001299686,0.0002357455,0.001071129,0.0001142002,0.000104013,0.00008695325,0.00001156784,0.00006418373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01218328,"threshold_uncertainty_score":0.3241321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026167357481095,"score_gpt":0.3128247802196673,"score_spread":0.3025631066448563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}