{"id":"W3082658746","doi":"10.2217/fon-2020-0740","title":"Sequential Afatinib and Osimertinib in Patients with <i>EGFR</i> Mutation-Positive Non-Small-Cell Lung Cancer: Final Analysis of the GioTag Study","year":2020,"lang":"en","type":"article","venue":"Future Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Boehringer Ingelheim","keywords":"Afatinib; Osimertinib; Medicine; Lung cancer; Internal medicine; Oncology; T790M; Clinical trial; Cancer; Adenocarcinoma; Erlotinib; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002368081,0.0005167819,0.001008301,0.0003557856,0.0002199771,0.0009163434,0.0004255683,0.0004738676,0.0009140117],"category_scores_gemma":[0.001484398,0.0002328733,0.002236446,0.00095761,0.0003703412,0.0005044439,0.0005094641,0.0007834727,0.0001668103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009222961,"about_ca_system_score_gemma":0.001051516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002257982,"about_ca_topic_score_gemma":0.00835734,"domain_scores_codex":[0.9991353,0.0003876228,0.00007527884,0.0001620452,0.0001239392,0.0001157601],"domain_scores_gemma":[0.9988652,0.0002376991,0.0004243897,0.0001249266,0.00008802368,0.0002597801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.108805,0.000564069,0.8276692,0.0007095492,0.009942994,0.0003424173,0.0002356479,0.001424467,0.003801826,0.0001756499,0.003379095,0.04295009],"study_design_scores_gemma":[0.0184868,0.01084722,0.9564753,0.0001122485,0.006771218,0.0007327101,0.0002509178,0.001105318,0.0008231138,0.0003181447,0.004027954,0.00004903503],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943067,0.003158758,0.0001117055,0.0001754537,0.00001935893,0.00009617263,0.001455448,0.000009362241,0.0006669314],"genre_scores_gemma":[0.9962908,0.0005907025,0.000183732,0.0001604805,0.0000245845,0.00006901472,0.002527304,0.000004754605,0.0001486554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002368081,"threshold_uncertainty_score":0.01252377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026167357481095,"score_gpt":0.3128247802196673,"score_spread":0.3025631066448563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}