{"id":"W3082659809","doi":"10.1002/gps.5418","title":"Alzheimer's disease biomarkers as predictors of trajectories of depression and apathy in cognitively normal individuals, mild cognitive impairment<scp>,</scp> and Alzheimer's disease dementia","year":2020,"lang":"en","type":"article","venue":"International Journal of Geriatric Psychiatry","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; H. Lundbeck A/S; Servier; Alzheimer Nederland; Pfizer; Novartis Pharmaceuticals Corporation; AbbVie; Takeda Pharmaceutical Company; Eli Lilly and Company; GE Healthcare; Fujirebio US; BioClinica; Northern California Institute for Research and Education; Alzheimer's Drug Discovery Foundation; Merck; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apathy; Depression (economics); Dementia; Psychology; Alzheimer's disease; Disease; Psychiatry; Logistic regression; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Internal medicine; Cognition; Medicine; Clinical psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001289111,0.0003636792,0.0003683211,0.0006928242,0.000456779,0.001147424,0.0003369205,0.0005090679,0.0007538907],"category_scores_gemma":[0.004589217,0.000293749,0.0006068586,0.0007727094,0.0002496435,0.0006045794,0.0006965346,0.0008897544,0.0001171926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000445821,"about_ca_system_score_gemma":0.0005464428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01640501,"about_ca_topic_score_gemma":0.02046484,"domain_scores_codex":[0.9996338,0.0001148409,0.00003923023,0.00009376934,0.00005902424,0.00005944419],"domain_scores_gemma":[0.9984698,0.0003052614,0.0006426982,0.00009858869,0.0001402934,0.0003433138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001711618,0.00002413822,0.9984398,0.000004227879,0.00006078965,0.00002741635,0.00005759017,0.0001572533,0.00008427654,0.00002155804,0.00003803147,0.000913681],"study_design_scores_gemma":[0.000004926904,0.00005256171,0.998616,0.000004630102,0.00002166558,0.00006410088,0.00008201083,0.0009867453,0.00002310038,0.00009697366,0.00004429159,0.00000309097],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992695,0.0001789053,0.000113664,0.00005432332,0.000003072702,0.000006154203,0.0002583403,0.000003315482,0.0001127178],"genre_scores_gemma":[0.9991761,0.00008249655,0.0001631493,0.00001281337,0.00000303688,0.000006397625,0.0004135614,0.00000146653,0.0001410225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01640501,"threshold_uncertainty_score":0.03261906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374577360145264,"score_gpt":0.2900114943642099,"score_spread":0.2762657207627573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}