{"id":"W3082672799","doi":"10.1038/s41467-020-17953-4","title":"Wnt activation as a therapeutic strategy in medulloblastoma","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Princess Margaret Cancer Centre; Interface Biologics (Canada); University Health Network; University of Toronto; McMaster University; University of Calgary","funders":"Mach-Gaensslen Foundation of Canada; Ontario Institute for Cancer Research; McMaster University; Brain Tumour Foundation of Canada; Canadian Institutes of Health Research; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Wnt signaling pathway; Medulloblastoma; Context (archaeology); Cancer research; LRP5; Biology; Chemistry; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000755857,0.00007963023,0.0001446765,0.00006017027,0.00005454897,0.00001325263,0.0002535821,0.0001337285,0.0001229569],"category_scores_gemma":[0.00009548345,0.00007140513,0.00005329382,0.0004530881,0.00004520182,0.00005989601,0.00007249757,0.0007932415,0.00004325538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006714094,"about_ca_system_score_gemma":0.0001624951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000937178,"about_ca_topic_score_gemma":0.000342331,"domain_scores_codex":[0.9994195,0.0000588016,0.0001518546,0.0001285518,0.0001350364,0.0001062491],"domain_scores_gemma":[0.9991071,0.00008416635,0.00004860765,0.000598779,0.00007166275,0.00008971697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001580552,0.002397461,0.02870294,0.0003162945,0.0006190179,0.00003465924,0.008332174,0.0002100222,0.3190644,0.1819189,0.02284875,0.4339749],"study_design_scores_gemma":[0.003620228,0.0006625621,0.1170057,0.0001976406,0.0002113073,0.00003834917,0.00208357,0.001988679,0.03472848,0.001365422,0.83771,0.0003880575],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5126761,0.02887395,0.0002855416,0.3451127,0.0001479032,0.001652854,0.00002519729,0.0002812887,0.1109444],"genre_scores_gemma":[0.9906561,0.0008485457,0.0007449359,0.007478167,0.00004915152,0.00003708322,0.00005445823,0.00001311693,0.0001183868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8148612,"threshold_uncertainty_score":0.3446284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05358209672943485,"score_gpt":0.3558085851084017,"score_spread":0.3022264883789669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}