{"id":"W3082700859","doi":"10.1080/19382014.2020.1762471","title":"Pancreatic and duodenal homeobox-1 (PDX1) contributes to β-cell mass expansion and proliferation induced by Akt/PKB pathway","year":2020,"lang":"en","type":"article","venue":"Islets","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Juvenile Diabetes Research Foundation United States of America; U.S. Department of Veterans Affairs","keywords":"PDX1; Glucose homeostasis; Protein kinase B; Endocrinology; Internal medicine; Biology; Homeostasis; Cell biology; Cell growth; mTORC1; PI3K/AKT/mTOR pathway; Chemistry; Insulin; Signal transduction; Insulin resistance; Medicine; Biochemistry; Islet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002064024,0.0006195478,0.0002718102,0.0008309527,0.0002770181,0.0004904926,0.000298947,0.0004133582,0.004754329],"category_scores_gemma":[0.0001239516,0.0002874769,0.0003364259,0.0002456408,0.0004546047,0.0003881782,0.0003421827,0.00172704,0.0004522333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002743869,"about_ca_system_score_gemma":0.0002476431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002468139,"about_ca_topic_score_gemma":0.0003543225,"domain_scores_codex":[0.999862,0.00001664684,0.00001156402,0.00004593715,0.00003681374,0.00002706508],"domain_scores_gemma":[0.9998062,0.00001984183,0.00005925191,0.00001278754,0.000009223692,0.00009269589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008462337,0.000105913,0.001198858,0.0001045541,0.00001712527,0.00020312,0.0000233548,0.00007510295,0.9924954,0.0004671517,0.0001852214,0.004277932],"study_design_scores_gemma":[0.0001812776,0.0004774767,0.02719836,0.00003095006,0.00009447923,0.001274108,0.0001157061,0.001369475,0.9598795,0.0005714637,0.008791152,0.00001600003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883514,0.00188124,0.005052821,0.0004021951,0.0001574178,0.00003353594,0.001086563,0.0002204283,0.002814372],"genre_scores_gemma":[0.9874692,0.001457474,0.002732984,0.000156076,0.00004081102,0.00006375968,0.00110781,0.00007461474,0.006897166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004754329,"threshold_uncertainty_score":0.01590484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431563722375704,"score_gpt":0.2247626551535213,"score_spread":0.2104470179297643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}