{"id":"W3082705391","doi":"10.1186/s12885-020-07313-2","title":"Clinical benefit of immune checkpoint inhibitors approved by US Food and Drug Administration","year":2020,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; American Society of Clinical Oncology","keywords":"Medicine; Food and drug administration; Oncology; Internal medicine; Immune checkpoint; Clinical Oncology; Adverse effect; Immunotherapy; Pharmacology; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946148,0.0001092351,0.0002962042,0.00001747057,0.0000249748,0.000009421638,0.00004711505,0.00007914838,0.0001369552],"category_scores_gemma":[0.0000472505,0.00009387617,0.0001541035,0.0001189624,0.0001130839,0.00004363735,0.00002306269,0.0001189507,0.000001505664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003623584,"about_ca_system_score_gemma":0.0002005383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002923097,"about_ca_topic_score_gemma":0.000283727,"domain_scores_codex":[0.9989219,0.00002164888,0.0005514994,0.0002346607,0.0001534141,0.0001168706],"domain_scores_gemma":[0.9994727,0.00003887115,0.0001895854,0.0001399473,0.00005081787,0.000108101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02103857,0.0005662391,0.3243569,0.001264556,0.0007383843,0.000004854403,0.001620583,0.000003838726,0.4838578,0.0000781718,0.02709476,0.1393753],"study_design_scores_gemma":[0.01386172,0.00379633,0.2755613,0.000447372,0.0002997257,0.00001348046,0.0006060867,0.0003956531,0.5890363,0.0000352463,0.1155116,0.0004352476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869938,0.008357324,0.00005288521,0.003638731,0.0002147341,0.0003339766,0.00005891894,0.00002599746,0.0003235804],"genre_scores_gemma":[0.9972363,0.0009777227,0.0002865418,0.0008233705,0.0002928961,0.0000303698,0.00002479006,0.00001617459,0.0003118645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1389401,"threshold_uncertainty_score":0.3828159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03348437106737064,"score_gpt":0.3142044597034453,"score_spread":0.2807200886360747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}