{"id":"W3082719615","doi":"10.1056/nejmoa2019910","title":"Evolocumab in Pediatric Heterozygous Familial Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"Amgen","keywords":"Evolocumab; Familial hypercholesterolemia; PCSK9; Kexin; Proprotein convertase; Medicine; Alirocumab; Monoclonal antibody; Monoclonal; Heterozygote advantage; Internal medicine; Endocrinology; Cholesterol; Lipoprotein; LDL receptor; Antibody; Genetics; Biology; Immunology; Allele; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006369654,0.0003856428,0.00101303,0.0001322517,0.0002171556,0.0001791837,0.0001961402,0.0003850897,0.001206811],"category_scores_gemma":[0.0006868123,0.0001233835,0.0004216084,0.0001638208,0.0002864286,0.0001520706,0.0001550447,0.0007307092,0.0001300264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000369071,"about_ca_system_score_gemma":0.0005497902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004906997,"about_ca_topic_score_gemma":0.001157441,"domain_scores_codex":[0.9997464,0.0001303896,0.00002357888,0.00003188778,0.00003469142,0.00003309315],"domain_scores_gemma":[0.9995437,0.0001629137,0.0001312876,0.00001459785,0.00002473437,0.0001226533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3296835,0.006829419,0.1490942,0.004872013,0.00187176,0.005871683,0.0004659028,0.002721046,0.04438129,0.0009873309,0.007554093,0.4456678],"study_design_scores_gemma":[0.2697152,0.3233508,0.3339048,0.0009877627,0.002864454,0.0182268,0.0004227742,0.003496384,0.02029396,0.0005550834,0.02612928,0.00005285557],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98699,0.01110713,0.0002950277,0.0003142282,0.00007620817,0.0001528726,0.0001043242,0.0000209232,0.0009392794],"genre_scores_gemma":[0.9942722,0.004051803,0.0006536466,0.0003383894,0.00009754642,0.0001794199,0.0001389154,0.000003957338,0.0002641274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001206811,"threshold_uncertainty_score":0.004037201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02411238369754403,"score_gpt":0.2695301940061424,"score_spread":0.2454178103085984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}