{"id":"W3082734312","doi":"10.1172/jci.insight.142362","title":"A simple protein-based surrogate neutralization assay for SARS-CoV-2","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Canadian Blood Services; Sunnybrook Health Science Centre; St. Michael's Hospital; University of Toronto; National Research Council Canada; Sinai Health System; Sunnybrook Hospital; Health Sciences Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Krembil Foundation; Canada Foundation for Innovation; Canada Research Chairs; Government of Ontario; Royal Bank of Canada; Canadian Institutes of Health Research; Genome Canada; Ontario Genomics; New York State Department of Health","keywords":"Antibody; Virology; Neutralization; Virus; Immune system; Coronavirus; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Viral load; Neutralizing antibody; Immunology; Medicine; Coronavirus disease 2019 (COVID-19); Biology; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002402878,0.0001988082,0.0003311289,0.0001259272,0.0001074086,0.00005904821,0.000161357,0.0001493487,0.00001764782],"category_scores_gemma":[0.0005762421,0.0001697036,0.0001716591,0.0005362629,0.00006085217,0.0001095052,0.00003852205,0.0002110125,0.0001456437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008813088,"about_ca_system_score_gemma":0.0004201694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008831785,"about_ca_topic_score_gemma":0.0000505708,"domain_scores_codex":[0.9983695,0.00008420205,0.0003021204,0.0004206191,0.0004161755,0.0004073385],"domain_scores_gemma":[0.9991426,0.0001312487,0.00007857134,0.0003096172,0.0002722635,0.00006572004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008820536,0.0002046795,0.004346238,0.0005222325,0.00005099763,0.0000698744,0.0003720523,0.000003787098,0.9835352,0.0006882671,0.007529309,0.001795354],"study_design_scores_gemma":[0.001884003,0.0004524172,0.0001878006,0.00003159683,0.0000259493,0.000001480443,0.0000129466,0.01030114,0.5600472,0.0001296172,0.426812,0.0001138145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627214,0.0001909936,0.01971403,0.007924174,0.0001152693,0.003342944,0.00004122279,0.0003612636,0.005588727],"genre_scores_gemma":[0.8872764,6.064235e-7,0.0005096478,0.111398,0.0003503467,0.0003149563,0.00005349702,0.00005796738,0.00003865574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4234879,"threshold_uncertainty_score":0.6920311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08930587795621657,"score_gpt":0.3611022360256936,"score_spread":0.2717963580694771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}