{"id":"W3082781138","doi":"10.1002/cncr.33145","title":"Phase 1 study of the immunotoxin LMB‐100 in patients with mesothelioma and other solid tumors expressing mesothelin","year":2020,"lang":"en","type":"article","venue":"Cancer","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; Chugai Pharmaceutical; Genentech; National Institutes of Health; Ipsen; Astellas Pharma; Springworks Therapeutics; Regeneron Pharmaceuticals; Array BioPharma; F. Hoffmann-La Roche; Sanofi; GlaxoSmithKline; Les Laboratories Pierre Fabre; MorphoSys; PharmaMar; Celgene; Bayer; Symphogen; Bristol-Myers Squibb; AstraZeneca; Pfizer","keywords":"Mesothelin; Medicine; Mesothelioma; Immunotoxin; Oncology; Pathology; Immunology; Antibody; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002094389,0.00007661297,0.0001412086,0.00001926428,0.00002597985,0.00000398581,0.00004503591,0.00001320831,0.0001761138],"category_scores_gemma":[0.000009360972,0.0000442715,0.00001796653,0.00009181191,0.00006163029,0.00003296456,0.00003117993,0.00005056172,0.000001739394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002778678,"about_ca_system_score_gemma":0.00002731074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008997228,"about_ca_topic_score_gemma":0.000009893984,"domain_scores_codex":[0.9994609,0.00002372979,0.0001308843,0.0001288327,0.0001794081,0.00007627792],"domain_scores_gemma":[0.9997738,0.000009929679,0.00005643964,0.000100696,0.000009343802,0.00004976392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001316925,0.001173765,0.9890065,0.00003381296,0.00003536837,0.000002310445,0.001896903,0.00005759963,0.004472625,0.000001221825,0.000051078,0.001951847],"study_design_scores_gemma":[0.008067418,0.000821533,0.9861647,0.0001679816,0.00005456084,2.706252e-7,0.0005981392,0.00009042108,0.003791712,0.000003644328,0.0001767152,0.00006285857],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989255,0.0003288596,0.000001456315,0.0001591288,0.00001522139,0.0004158386,0.00004862732,0.000006195545,0.00009917499],"genre_scores_gemma":[0.9990419,0.000003953171,0.00001813063,0.0008161261,0.00002883031,0.00003247336,0.000002245103,0.00001430609,0.0000419945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006750493,"threshold_uncertainty_score":0.1928322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782408840962632,"score_gpt":0.2940308275031155,"score_spread":0.2762067390934892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}