{"id":"W3082781138","doi":"10.1002/cncr.33145","title":"Phase 1 study of the immunotoxin LMB‐100 in patients with mesothelioma and other solid tumors expressing mesothelin","year":2020,"lang":"en","type":"article","venue":"Cancer","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; Chugai Pharmaceutical; Genentech; National Institutes of Health; Ipsen; Astellas Pharma; Springworks Therapeutics; Regeneron Pharmaceuticals; Array BioPharma; F. Hoffmann-La Roche; Sanofi; GlaxoSmithKline; Les Laboratories Pierre Fabre; MorphoSys; PharmaMar; Celgene; Bayer; Symphogen; Bristol-Myers Squibb; AstraZeneca; Pfizer","keywords":"Mesothelin; Medicine; Mesothelioma; Immunotoxin; Oncology; Pathology; Immunology; Antibody; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008425404,0.001146524,0.001199876,0.0002934464,0.0004189336,0.0006896463,0.0006190142,0.00089844,0.001977546],"category_scores_gemma":[0.000524082,0.0004741639,0.0007187558,0.0002295693,0.000583247,0.0004775697,0.000288415,0.002724262,0.0005412607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008662508,"about_ca_system_score_gemma":0.001249291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006683347,"about_ca_topic_score_gemma":0.001685011,"domain_scores_codex":[0.9997911,0.00008912428,0.000006998624,0.000037557,0.00002591889,0.00004938084],"domain_scores_gemma":[0.9995567,0.00007309997,0.00009642573,0.00003368226,0.00003143661,0.0002086651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3403957,0.1526065,0.04732574,0.001414268,0.001469346,0.002041535,0.001316852,0.007645293,0.2416324,0.0007732583,0.01108854,0.1922905],"study_design_scores_gemma":[0.2564286,0.6743684,0.03965227,0.00006349009,0.0003951956,0.001871625,0.0001203857,0.002818076,0.01733661,0.0003292807,0.006584913,0.00003108199],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961264,0.0009419115,0.0003691054,0.0002931524,0.0000402395,0.001023588,0.0003043942,0.00004236359,0.0008589373],"genre_scores_gemma":[0.9936133,0.0008862483,0.001016847,0.0005820295,0.00006878613,0.001260605,0.001009047,0.00001723186,0.001545839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001977546,"threshold_uncertainty_score":0.00661552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782408840962632,"score_gpt":0.2940308275031155,"score_spread":0.2762067390934892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}