{"id":"W3082817015","doi":"10.1101/2020.08.28.270306","title":"<i>Prunella vulgaris</i> extract and suramin block SARS-coronavirus <i>2</i> virus Spike protein D614 and G614 variants mediated receptor association and virus entry in cell culture system","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Research Manitoba","keywords":"Suramin; Virology; Infectivity; Cytopathic effect; Biology; Vero cell; Virus; Viral entry; Coronavirus; Cell culture; Receptor; Viral replication; Medicine; Coronavirus disease 2019 (COVID-19); Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001023374,0.0009532208,0.001259547,0.0002324739,0.0002962975,0.0002773545,0.000408976,0.002402713,0.00003787349],"category_scores_gemma":[0.0002746819,0.0009858432,0.0001101043,0.0003545152,0.000163694,0.0002271522,0.0007324322,0.002160759,0.0001100898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532755,"about_ca_system_score_gemma":0.0003046013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007177881,"about_ca_topic_score_gemma":0.0000448385,"domain_scores_codex":[0.9956013,0.0007235995,0.001003066,0.001603324,0.0001937123,0.0008750227],"domain_scores_gemma":[0.9978176,0.0001532745,0.0009856432,0.0006827365,0.0001841726,0.0001765658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002520771,0.0002159851,0.002429339,0.0006910557,0.0002496672,0.00006729913,0.0001330107,0.000001016989,0.9953266,0.0001381596,0.0004864667,0.000009352214],"study_design_scores_gemma":[0.002865517,0.0002141329,0.01809398,0.0007860417,0.0001975311,5.488685e-7,0.00004691132,0.00005139352,0.9638645,0.000003332831,0.01275001,0.001126119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796118,0.01490528,0.0000644262,0.0001322193,0.001345161,0.001921361,0.00166483,0.000332008,0.00002289758],"genre_scores_gemma":[0.9942809,0.004031852,0.0008292065,0.0002322944,0.0001441284,0.0002468837,0.00001209521,0.0001472172,0.00007536179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03146209,"threshold_uncertainty_score":0.9992592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009911669885688635,"score_gpt":0.2004766782098553,"score_spread":0.1905650083241667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}