{"id":"W3082817015","doi":"10.1101/2020.08.28.270306","title":"<i>Prunella vulgaris</i> extract and suramin block SARS-coronavirus <i>2</i> virus Spike protein D614 and G614 variants mediated receptor association and virus entry in cell culture system","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"Canadian Institutes of Health Research; Research Manitoba","keywords":"Suramin; Virology; Infectivity; Cytopathic effect; Biology; Vero cell; Virus; Viral entry; Coronavirus; Cell culture; Receptor; Viral replication; Medicine; Coronavirus disease 2019 (COVID-19); Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007131135,0.0002651299,0.0002037535,0.0001070029,0.00008927542,0.000146737,0.0001645618,0.0001801269,0.0007153207],"category_scores_gemma":[0.00007081132,0.00007675821,0.0002135065,0.00007216015,0.0001317733,0.0001159589,0.0001100277,0.0003428962,0.0002166795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001371986,"about_ca_system_score_gemma":0.0001331442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007301731,"about_ca_topic_score_gemma":0.0007624715,"domain_scores_codex":[0.9999114,0.00001943377,0.000009998268,0.00001124445,0.00002342989,0.00002441482],"domain_scores_gemma":[0.9999624,0.000009256737,0.00000929482,0.000005223108,0.000004690554,0.000009174327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001551776,0.00004515766,0.0000688108,0.00003085393,0.000004639804,0.00003447492,0.000006237253,0.00003754703,0.9989206,0.0000247245,0.00002887586,0.0006429669],"study_design_scores_gemma":[0.00002374012,0.0008088062,0.002069492,0.000004035448,0.00001225543,0.0001454865,0.00001991443,0.0005800543,0.9950551,0.00001457867,0.001264459,0.000002136144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995882,0.001746863,0.0007876042,0.00006108261,0.00002705377,0.00002145828,0.0001393201,0.00003191634,0.001302665],"genre_scores_gemma":[0.9966714,0.0007907866,0.000846152,0.00004314008,0.00001098943,0.00001979211,0.0003601469,0.000005707548,0.001251916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007301731,"threshold_uncertainty_score":0.002392948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009911669885688635,"score_gpt":0.2004766782098553,"score_spread":0.1905650083241667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}