{"id":"W3082851951","doi":"10.7554/elife.58675","title":"Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Kato Memorial Bioscience Foundation; National Natural Science Foundation of China; Wellcome Trust; Akiyama Life Science Foundation; Takeda Science Foundation","keywords":"PRC2; PHD finger; Cell biology; Polycomb-group proteins; Histone; Histone H3; Gene silencing; Biology; Hox gene; Chemistry; Genetics; Zinc finger; Transcription factor; Gene; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000767978,0.00008763774,0.00008658365,0.000009732346,0.00006328088,0.00001755215,0.00004705563,0.00008586747,0.00002297332],"category_scores_gemma":[0.0001550361,0.00008670008,0.00003761673,0.00003108697,0.0000245048,0.000002713351,0.00003007279,0.00003509619,0.000004035136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006133484,"about_ca_system_score_gemma":0.00001901809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009760966,"about_ca_topic_score_gemma":0.000004261761,"domain_scores_codex":[0.9994292,0.00002206357,0.0001247162,0.0002376757,0.00007150835,0.0001148682],"domain_scores_gemma":[0.9996976,0.00001266637,0.0000508414,0.00008368462,0.00006345902,0.00009180517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007688917,0.00000806714,0.0003179232,0.00002153693,0.00002330616,5.164088e-7,0.00008195923,0.00000721366,0.9758525,0.0000161064,0.005349886,0.01824405],"study_design_scores_gemma":[0.0006716624,0.0003941358,0.001119913,0.0000049728,0.00002968432,0.000001860198,0.00003374305,0.0008854692,0.8972706,0.000165331,0.09922041,0.0002022539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859545,0.003061394,0.009249972,0.0009623084,0.000108981,0.000189203,0.0001698135,0.00001149009,0.0002923743],"genre_scores_gemma":[0.9943959,0.0004301,0.003207687,0.0009121147,0.0003568588,0.00001832448,0.0005336092,0.00001697271,0.00012847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09387052,"threshold_uncertainty_score":0.3535527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414762821668548,"score_gpt":0.2711431252981195,"score_spread":0.246995497081434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}