{"id":"W3082851951","doi":"10.7554/elife.58675","title":"Structural basis for histone variant H3tK27me3 recognition by PHF1 and PHF19","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Kato Memorial Bioscience Foundation; National Natural Science Foundation of China; Wellcome Trust; Akiyama Life Science Foundation; Takeda Science Foundation","keywords":"PRC2; PHD finger; Cell biology; Polycomb-group proteins; Histone; Histone H3; Gene silencing; Biology; Hox gene; Chemistry; Genetics; Zinc finger; Transcription factor; Gene; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007019581,0.0001301388,0.0001125347,0.0001179555,0.0003367842,0.0001763036,0.0003608641,0.000295039,0.002784012],"category_scores_gemma":[0.000134316,0.0001178869,0.0002275414,0.00008849064,0.000224248,0.0001937493,0.0002614988,0.0002891529,0.0005785652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005248762,"about_ca_system_score_gemma":0.0002103058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001604462,"about_ca_topic_score_gemma":0.002422046,"domain_scores_codex":[0.9999269,0.000005185506,0.000002458986,0.00002619511,0.00001365544,0.00002550137],"domain_scores_gemma":[0.9999373,0.000005812045,0.00001591305,0.000006286189,0.0000067514,0.00002790976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002432612,0.00002634562,0.002460729,0.00005524778,0.00001249974,0.0002244909,0.00004311155,0.0004495982,0.9914405,0.001622437,0.0001668598,0.003254881],"study_design_scores_gemma":[0.00005519416,0.0001859699,0.05284554,0.00001034372,0.00001928082,0.0008162496,0.0001267125,0.007223072,0.9281046,0.001212376,0.009381451,0.00001910144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895746,0.0009627937,0.005559738,0.0001653579,0.0000328556,0.00001802414,0.000274414,0.00007712012,0.003334989],"genre_scores_gemma":[0.9968941,0.000168164,0.001054151,0.00004220704,0.000004898033,0.000007283044,0.0002896047,0.000009123961,0.001530506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002784012,"threshold_uncertainty_score":0.009313464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414762821668548,"score_gpt":0.2711431252981195,"score_spread":0.246995497081434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}