{"id":"W3082941820","doi":"10.1084/jem.20191688","title":"Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome","year":2020,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"FP7 People: Marie-Curie Actions; European Research Council; Institut National Du Cancer; Natural Sciences and Engineering Research Council of Canada; Ministère de l'Enseignement Supérieur et de la Recherche; Ligue Contre le Cancer; Agence Nationale de la Recherche; Fondation ARC pour la Recherche sur le Cancer; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation pour la Recherche Médicale; KWF Kankerbestrijding; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Immunoglobulin class switching; PARP1; Poly ADP ribose polymerase; Biology; Genetics; V(D)J recombination; Genome instability; Polymerase; Non-homologous end joining; DNA repair; Molecular biology; DNA; Mutation; Gene; Recombination; DNA damage; Antibody; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709259,0.000754634,0.0004466627,0.0005762513,0.0002613625,0.0003550437,0.0001948622,0.0006723657,0.002225634],"category_scores_gemma":[0.0002698267,0.0001838668,0.0002222188,0.0002858941,0.0003001581,0.0001539129,0.0002004218,0.0003516459,0.0002618209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002286322,"about_ca_system_score_gemma":0.0001601181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110486,"about_ca_topic_score_gemma":0.0007410834,"domain_scores_codex":[0.9998668,0.00002384182,0.00001606985,0.00003256796,0.00003167064,0.00002898956],"domain_scores_gemma":[0.999879,0.00001801046,0.00003695186,0.000007137758,0.000007890822,0.00005101843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002265049,0.0002742926,0.04944688,0.0001036172,0.0001512164,0.01190537,0.0002780674,0.0005189891,0.9170218,0.0003507574,0.0006844847,0.01699949],"study_design_scores_gemma":[0.0005498176,0.002473418,0.6202047,0.00004288451,0.0003042651,0.1110578,0.000339567,0.003823157,0.2545909,0.0004691564,0.00610107,0.000043246],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998606,0.0003587665,0.0003512608,0.00005389335,0.000005813342,0.000006505037,0.0001420609,0.00004243638,0.0004332454],"genre_scores_gemma":[0.9992487,0.000127629,0.0001859757,0.0000219239,0.000004225888,0.000004507087,0.0001246935,0.000006905803,0.0002754649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002225634,"threshold_uncertainty_score":0.007445514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879032027998686,"score_gpt":0.2878766422145968,"score_spread":0.26908632193461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}