{"id":"W3082945900","doi":"10.1182/bloodadvances.2020001879","title":"Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734","year":2020,"lang":"en","type":"article","venue":"Blood Advances","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"NEOMED Institute; McGill University","funders":"","keywords":"Bromodomain; Cancer research; Acetylation; Biology; In vivo; Prostate cancer; In vitro; Pharmacology; Chemistry; Cancer; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003852508,0.00008039338,0.00009313969,0.000007235482,0.00005258846,0.000009562609,0.0000851646,0.00004193049,0.000006664672],"category_scores_gemma":[0.0001027206,0.00005744733,0.00004292627,0.00006734494,0.0001047062,0.000009237258,0.0001080592,0.00005400532,0.000001184323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001012832,"about_ca_system_score_gemma":0.00002835585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003661685,"about_ca_topic_score_gemma":0.000007663285,"domain_scores_codex":[0.9995067,0.0000328573,0.00009875261,0.0001813857,0.00009107457,0.00008925761],"domain_scores_gemma":[0.9997094,0.000006119079,0.00008112712,0.0001282367,0.00002662618,0.00004849744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003647015,0.0000398003,0.005454531,0.00003264785,0.00001547745,7.547125e-7,0.00002507869,0.000003764738,0.990851,0.00006933023,0.0005543498,0.0029168],"study_design_scores_gemma":[0.0003703514,0.000159362,0.00327446,0.00001051387,0.00001241736,0.000004246943,0.00002625195,0.000007269024,0.9445068,0.0000198871,0.05153468,0.00007372974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962567,0.001934594,0.00006963078,0.001002847,0.0001043425,0.0001300428,0.00002644989,0.000007671331,0.0004677272],"genre_scores_gemma":[0.9987821,0.0002074317,0.0003124167,0.0003122128,0.0002616732,0.000005618334,0.00000577573,0.000006739115,0.0001060605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05098033,"threshold_uncertainty_score":0.2342634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007588730780189812,"score_gpt":0.2201553180888164,"score_spread":0.2125665873086266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}