{"id":"W3083004448","doi":"10.1158/1538-7445.am2020-5231","title":"Abstract 5231: Dianhydrogalactitol (VAL-083) exhibits strong efficacy in GBM tumors with different (epi)genetic background and treatment history","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Delmar (Canada)","funders":"","keywords":"Temozolomide; Bevacizumab; Cancer research; Brain tumor; Medicine; O-6-methylguanine-DNA methyltransferase; Methyltransferase; In vivo; Glioma; Oncology; Internal medicine; Chemotherapy; Biology; Pathology; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007280926,0.0003385486,0.0002743945,0.0002097579,0.0001159712,0.0001643788,0.0001531159,0.0001832881,0.002526713],"category_scores_gemma":[0.0000502201,0.00008073103,0.0001886048,0.0002434064,0.0001229501,0.0001161679,0.0001385447,0.0004572619,0.0004478599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002336541,"about_ca_system_score_gemma":0.0002851539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001125854,"about_ca_topic_score_gemma":0.001282817,"domain_scores_codex":[0.9999517,0.0000070355,0.000003810786,0.000009972445,0.0000120323,0.00001544803],"domain_scores_gemma":[0.9999663,0.000002619255,0.000006039741,0.000003544727,0.000004564304,0.00001697518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003272056,0.0007817753,0.000765641,0.0001811023,0.00004105639,0.0001216468,0.00003296052,0.0003618117,0.9743304,0.0001442152,0.001191873,0.01877551],"study_design_scores_gemma":[0.0007569466,0.01451143,0.01046993,0.00001760199,0.0001448051,0.0007947218,0.00004202158,0.0009822269,0.9582818,0.00008017348,0.01390076,0.00001756342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935526,0.001901205,0.0004820249,0.0001218179,0.00005426625,0.00007235826,0.001239339,0.0001044039,0.002471939],"genre_scores_gemma":[0.9911576,0.001299673,0.0009609142,0.0001208235,0.00001359553,0.000084733,0.00294659,0.00003098815,0.003385058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002526713,"threshold_uncertainty_score":0.008452654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1527323420709229,"score_gpt":0.3783925297844439,"score_spread":0.225660187713521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}