{"id":"W3083020346","doi":"10.3389/fimmu.2020.02153","title":"Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Peter MacCallum Cancer Centre; University of Melbourne","keywords":"Multiple myeloma; CD8; Cytotoxic T cell; Stem cell; Immunology; Biology; Cancer research; T cell; Immune system; Medicine; Cell biology; Internal medicine; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001957807,0.0002506746,0.0002949982,0.0003089395,0.0002194278,0.0004023853,0.0001222641,0.0002543261,0.001148291],"category_scores_gemma":[0.0001934547,0.0001048271,0.0002293462,0.0003405821,0.0001866067,0.0001857811,0.0002780858,0.0004219476,0.0003190153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000257319,"about_ca_system_score_gemma":0.00019132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003755952,"about_ca_topic_score_gemma":0.0005204716,"domain_scores_codex":[0.999835,0.0000249599,0.00001162948,0.00004546002,0.00005056808,0.00003231872],"domain_scores_gemma":[0.9998671,0.00001512438,0.00005958902,0.00001318789,0.00002255442,0.00002248494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004539324,0.00007475305,0.01944492,0.0001750562,0.00004080895,0.0003452035,0.0001575272,0.0002160349,0.9502695,0.0002220484,0.0004889077,0.02811122],"study_design_scores_gemma":[0.00006537231,0.002631807,0.5335895,0.00009841916,0.0001803454,0.005059283,0.0005957626,0.001646116,0.4188121,0.001419659,0.03587217,0.00002954203],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823309,0.01050322,0.003822425,0.0003000001,0.00005417965,0.00004073207,0.0007219485,0.000170819,0.002055651],"genre_scores_gemma":[0.9926197,0.003176903,0.001702766,0.0002936086,0.0000392185,0.00006004109,0.0005270935,0.000021742,0.001559159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148291,"threshold_uncertainty_score":0.0038414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857904638328338,"score_gpt":0.2665837694090165,"score_spread":0.2480047230257331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}