{"id":"W3083055113","doi":"10.1158/1538-7445.am2020-ct301","title":"Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Atezolizumab; Medicine; Immunotherapy; Internal medicine; Adverse effect; Pembrolizumab; Oncology; Cancer; Melanoma; Immune system; Gastroenterology; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006953693,0.001216511,0.001360768,0.0003506712,0.0003295204,0.0007147531,0.0006031201,0.000981465,0.003221581],"category_scores_gemma":[0.0004292183,0.0003453276,0.0007671487,0.0003533679,0.0006659282,0.0005138982,0.0002465521,0.002312456,0.001081233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007549289,"about_ca_system_score_gemma":0.001255323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009240377,"about_ca_topic_score_gemma":0.001663428,"domain_scores_codex":[0.9997525,0.00009460915,0.00001442977,0.00005047203,0.00002738052,0.00006057377],"domain_scores_gemma":[0.999631,0.00004051145,0.00005774852,0.00003194409,0.00002666317,0.000211947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4598542,0.09976611,0.01520928,0.001350063,0.000974422,0.001077248,0.0003751077,0.003998541,0.2811477,0.0004911846,0.006043557,0.1297125],"study_design_scores_gemma":[0.1750877,0.7916387,0.01561998,0.00004957591,0.0003127395,0.0008029407,0.0000588017,0.001262587,0.01191366,0.0001060039,0.003120644,0.00002676999],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939073,0.001072689,0.0004058342,0.0002375095,0.00006389849,0.001557828,0.0009262452,0.00009092925,0.001737757],"genre_scores_gemma":[0.9913411,0.0007834053,0.0008697445,0.0003949689,0.00007972928,0.001499076,0.002634712,0.00001779943,0.002379533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003221581,"threshold_uncertainty_score":0.01077724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07132464025938938,"score_gpt":0.4066681266226377,"score_spread":0.3353434863632483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}