{"id":"W3083055113","doi":"10.1158/1538-7445.am2020-ct301","title":"Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Atezolizumab; Medicine; Immunotherapy; Internal medicine; Adverse effect; Pembrolizumab; Oncology; Cancer; Melanoma; Immune system; Gastroenterology; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001485661,0.0003893816,0.0007622894,0.0007030998,0.0002505952,0.00009425053,0.0006855174,0.00008941899,0.001299005],"category_scores_gemma":[0.0001169225,0.0002767984,0.00004370018,0.001791824,0.0002713312,0.0003753918,0.00009377961,0.0008660114,0.0001449818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003338331,"about_ca_system_score_gemma":0.0008298759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006450758,"about_ca_topic_score_gemma":0.0007071521,"domain_scores_codex":[0.995477,0.00166295,0.0007131301,0.0007666822,0.0004220504,0.0009582211],"domain_scores_gemma":[0.9985406,0.0002605141,0.0001755683,0.0004825576,0.0004545106,0.00008627732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4607518,0.01209584,0.03794463,0.0001041546,0.0008254605,0.0002877106,0.04227798,0.001280791,0.2669763,0.00002508059,0.0001840803,0.1772462],"study_design_scores_gemma":[0.1553667,0.04619025,0.7402616,0.0006900115,0.00003033188,0.00001003776,0.007820789,0.00002505825,0.0457959,0.00003487528,0.00288837,0.0008861533],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928363,0.002077569,0.00005156906,0.0003713711,0.00007487601,0.004451739,0.00005620332,0.00005029456,0.00003011075],"genre_scores_gemma":[0.9981661,0.0003066612,0.0001040454,0.0002054029,0.00001195639,0.0007975408,0.0001247034,0.0000873134,0.0001962662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7023169,"threshold_uncertainty_score":0.9999684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07132464025938938,"score_gpt":0.4066681266226377,"score_spread":0.3353434863632483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}