{"id":"W3083062597","doi":"10.1158/1538-7445.am2020-4899","title":"Abstract 4899: Investigating mutation co-operativity in early tumorigenesis of low-grade serous ovarian carcinoma with organoid model system and single-cell RNA sequencing","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Organoid; Neuroblastoma RAS viral oncogene homolog; KRAS; Carcinogenesis; Biology; Serous fluid; Cancer research; Ovarian carcinoma; Serous carcinoma; Ovarian cancer; Mutation; Gene; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003374223,0.000223072,0.0002289882,0.0004796,0.000270572,0.0003184379,0.0002110361,0.0003224224,0.001422156],"category_scores_gemma":[0.0002192022,0.0001455054,0.0003524765,0.0003007838,0.0002224284,0.0001582086,0.0002124329,0.0003774999,0.0004805869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003207166,"about_ca_system_score_gemma":0.0003019042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001033669,"about_ca_topic_score_gemma":0.001975656,"domain_scores_codex":[0.999775,0.00002929323,0.00001776168,0.00007792033,0.00006902937,0.00003105096],"domain_scores_gemma":[0.9997919,0.00004847845,0.00005400528,0.00003939969,0.00003594321,0.00003017574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008423584,0.00003346522,0.001567194,0.00004310161,0.000007294118,0.00008158121,0.00004390341,0.0001741762,0.9964048,0.00007856542,0.00007313834,0.001408658],"study_design_scores_gemma":[0.00002835985,0.000846784,0.02648551,0.00001488028,0.00007425965,0.0007904955,0.000203352,0.005545854,0.9579956,0.0001625095,0.007830282,0.00002219009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717078,0.001298031,0.02116212,0.00008574635,0.00007255792,0.0001696926,0.003374532,0.0002654375,0.001864191],"genre_scores_gemma":[0.96881,0.0008193444,0.02171015,0.0001104335,0.00001030021,0.00034846,0.004537093,0.00009342524,0.003560798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422156,"threshold_uncertainty_score":0.004757643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06275420631186224,"score_gpt":0.3019909241421818,"score_spread":0.2392367178303196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}