{"id":"W3083066627","doi":"10.1158/1538-7445.am2020-5730","title":"Abstract 5730: A new polyphenol prebiotic isolated from <i>Myrciaria dubia</i> improves gut microbiota composition and increases anti-PD-1 efficacy in murine cancer models","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; Computer Research Institute of Montréal","funders":"","keywords":"Akkermansia; Gut flora; Prebiotic; Biology; Feces; Akkermansia muciniphila; Microbiology; Antibiotics; Immunology; Biochemistry; Lactobacillus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004411231,0.0003004828,0.0002561402,0.0002920509,0.00009585612,0.0001622285,0.0001245994,0.0001312896,0.00182474],"category_scores_gemma":[0.00005182168,0.00007755356,0.0002028842,0.000116173,0.0001047573,0.0001267414,0.0001344307,0.0003473433,0.000329741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001094927,"about_ca_system_score_gemma":0.0001425457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000380803,"about_ca_topic_score_gemma":0.0005702467,"domain_scores_codex":[0.9999688,0.000004207086,0.000002682123,0.000008005185,0.000008884575,0.000007400961],"domain_scores_gemma":[0.9999694,0.00000267759,0.000009107414,0.000002611735,0.000004797573,0.00001149634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003626898,0.00008220845,0.0001411581,0.00009411916,0.00001095105,0.00002702656,0.000004905112,0.00003450017,0.9948857,0.00003850054,0.00009541551,0.004222801],"study_design_scores_gemma":[0.00009506264,0.002258513,0.008355351,0.00002573786,0.00007868181,0.0002377061,0.00002669641,0.0004267435,0.9800744,0.00005394232,0.008356304,0.00001082169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920734,0.002430709,0.002019673,0.0001394157,0.0000594556,0.00005827883,0.00076063,0.0001669182,0.002291631],"genre_scores_gemma":[0.9899755,0.001456622,0.003219842,0.0001622557,0.00002183573,0.0000290325,0.0009464721,0.00005903418,0.004129434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00182474,"threshold_uncertainty_score":0.00610435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04830652355737396,"score_gpt":0.3509937508628041,"score_spread":0.3026872273054301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}