{"id":"W3083070660","doi":"10.1158/1538-7445.am2020-ct147","title":"Abstract CT147: Phase 1 dose escalation of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Neutropenia; Internal medicine; Tumor microenvironment; Adverse effect; Oncology; Radioimmunotherapy; Cancer; Monoclonal antibody; Antibody; Immunology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009269093,0.0009587566,0.001282374,0.0004984565,0.000273906,0.0006719864,0.0005547675,0.0006458413,0.003044911],"category_scores_gemma":[0.0005721936,0.0003124076,0.0006916489,0.0003750378,0.0004513773,0.0003454829,0.0003235031,0.002148052,0.0005798037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009464528,"about_ca_system_score_gemma":0.001285397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008123972,"about_ca_topic_score_gemma":0.001599565,"domain_scores_codex":[0.9996783,0.0001446138,0.00001636288,0.00004505197,0.00004326998,0.00007254836],"domain_scores_gemma":[0.9997279,0.00004173363,0.00005410033,0.00003170546,0.00002474027,0.0001197214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3939879,0.07971209,0.02402017,0.0009632877,0.001018901,0.0005501691,0.00063377,0.009561439,0.2232336,0.001159949,0.01037498,0.2547837],"study_design_scores_gemma":[0.1925206,0.7473652,0.02646725,0.00006396882,0.0003714636,0.0005686323,0.00007804239,0.003851193,0.02193604,0.0003664843,0.006379526,0.00003153372],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945124,0.0007281592,0.0004835791,0.0001703365,0.00003288674,0.00203768,0.0007514876,0.00008136503,0.001202055],"genre_scores_gemma":[0.9904683,0.0005806765,0.002223996,0.0004312696,0.00006019077,0.002547464,0.001815334,0.00002607017,0.001846648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003044911,"threshold_uncertainty_score":0.0101862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08106162704801605,"score_gpt":0.4567553933471356,"score_spread":0.3756937662991195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}