{"id":"W3083088832","doi":"10.1158/1538-7445.am2020-lb-108","title":"Abstract LB-108: A potent and selective small molecule degrader of STAT5 for the treatment of hematological malignancies","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; University of Toronto","funders":"","keywords":"STAT5; Western blot; STAT protein; Chemistry; Small molecule; Gene isoform; Cancer research; STAT3; Phosphorylation; Molecular biology; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009501369,0.0002796921,0.0001459364,0.0002118276,0.00008784469,0.0001354372,0.0001575743,0.000226621,0.001361593],"category_scores_gemma":[0.00004955379,0.00007810589,0.0001762655,0.0001171316,0.0001162916,0.0001110525,0.0001205329,0.0004239753,0.0005067919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001708068,"about_ca_system_score_gemma":0.0001195067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003446218,"about_ca_topic_score_gemma":0.0006372074,"domain_scores_codex":[0.9999467,0.000008854621,0.000004268223,0.000009025286,0.00001865446,0.00001257092],"domain_scores_gemma":[0.9999732,0.0000039793,0.00000826206,0.000002620637,0.000004148521,0.000007856722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001893949,0.00006835475,0.0001320316,0.00006823907,0.000007977397,0.00006939266,0.000009187015,0.000133213,0.9926778,0.0000678936,0.0003280011,0.006248601],"study_design_scores_gemma":[0.00005950552,0.001542675,0.001943363,0.000008784868,0.00002000948,0.0004902838,0.000009096914,0.0008104703,0.9907478,0.00001668271,0.004344991,0.000006379235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770595,0.01006595,0.006605439,0.0002232986,0.00007403447,0.0001215734,0.0007922851,0.0003077118,0.004750092],"genre_scores_gemma":[0.9881251,0.002521385,0.003740769,0.0001365046,0.00001511805,0.00005315497,0.00100328,0.0000152836,0.004389445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361593,"threshold_uncertainty_score":0.004554927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1136847594250921,"score_gpt":0.3718578193550152,"score_spread":0.2581730599299231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}