{"id":"W3083097298","doi":"10.1158/1538-7445.am2020-5156","title":"Abstract 5156: Targeting N-myristoylation in B-cell lymphomas as a therapeutic strategy","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Myristoylation; Cancer research; Cell growth; Signal transduction; MAPK/ERK pathway; Cell culture; MCL1; B cell; Biology; Lymphoma; breakpoint cluster region; Apoptosis; Ibrutinib; Cell; CHOP; Viability assay; Kinase; Cell biology; Receptor; Immunology; Leukemia; Phosphorylation; Chronic lymphocytic leukemia; Downregulation and upregulation; Biochemistry; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147569,0.0004006577,0.0002940076,0.0002926928,0.0001252803,0.0003771822,0.0002331034,0.0003521926,0.001906958],"category_scores_gemma":[0.00007002512,0.0001174884,0.0002232566,0.0001931833,0.0001505559,0.0001998194,0.0002365245,0.0004973626,0.000648364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003569463,"about_ca_system_score_gemma":0.0002245895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005590807,"about_ca_topic_score_gemma":0.0007620651,"domain_scores_codex":[0.9999065,0.00001301062,0.000007622553,0.00001934757,0.00002825044,0.00002523895],"domain_scores_gemma":[0.9999722,0.000003655433,0.00000610662,0.000003892982,0.000004468995,0.000009778501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723291,0.00007545283,0.0001425431,0.00006983319,0.000007670491,0.00005619239,0.00001040715,0.0002987788,0.9926663,0.0001828914,0.0001927186,0.006124849],"study_design_scores_gemma":[0.00009777053,0.0009983123,0.001276357,0.000007950268,0.00002336353,0.0004242155,0.00001040028,0.0009528048,0.987561,0.00005485549,0.008586765,0.000006287459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763375,0.006066216,0.007183687,0.0003475463,0.00008032779,0.000247669,0.0009272909,0.0003363234,0.008473388],"genre_scores_gemma":[0.9874277,0.002459503,0.004541249,0.0001212797,0.00001419597,0.00009760893,0.0008077042,0.00002829912,0.004502422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906958,"threshold_uncertainty_score":0.006379426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08314408908031433,"score_gpt":0.372667622264723,"score_spread":0.2895235331844087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}