{"id":"W3083099135","doi":"10.1158/1538-7445.am2020-6559","title":"Abstract 6559: Novel anti-myeloma potential of CAPE analogs: Downregulation of IKZF1-IRF4-MYC axis","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital; Université de Moncton; University of New Brunswick","funders":"","keywords":"IRF4; Cancer research; Cyclin D1; Multiple myeloma; Transcription factor; Biology; Plasma cell; Chromosomal translocation; Molecular biology; Immunology; Cancer; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006911682,0.0003624161,0.000294331,0.0002596526,0.0001657368,0.000184235,0.0002162498,0.0002406475,0.003906987],"category_scores_gemma":[0.00006572448,0.00009936266,0.0002982037,0.000141124,0.0001384518,0.0002017896,0.0001402397,0.0006062955,0.0005603434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001796451,"about_ca_system_score_gemma":0.0001747057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005206956,"about_ca_topic_score_gemma":0.001198292,"domain_scores_codex":[0.9999712,0.000003315236,0.00000294697,0.000006646264,0.00000745372,0.000008438007],"domain_scores_gemma":[0.9999768,0.000002544149,0.000006075274,0.000001817899,0.000004033723,0.000008723992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009411587,0.0004381692,0.0004035218,0.0008272239,0.00005355983,0.0005921908,0.00003620733,0.0005458501,0.9731185,0.0005727797,0.001684499,0.0207862],"study_design_scores_gemma":[0.001325778,0.008366436,0.007468146,0.0001538355,0.0002285441,0.001737822,0.00007747449,0.001907687,0.9241719,0.0003927319,0.05412772,0.00004210404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9393343,0.03711837,0.003745243,0.0009155313,0.0004257539,0.0003973221,0.002330151,0.0002928129,0.01544048],"genre_scores_gemma":[0.9746121,0.01262876,0.002890461,0.0005486907,0.00006635876,0.0001235555,0.001562969,0.00002071146,0.007546445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003906987,"threshold_uncertainty_score":0.01307023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.054708050145159,"score_gpt":0.3346324765064247,"score_spread":0.2799244263612657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}