{"id":"W3083111306","doi":"10.3390/metabo10090363","title":"Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in Drosophila melanogaster","year":2020,"lang":"en","type":"article","venue":"Metabolites","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick; Université de Moncton","keywords":"Oxidative phosphorylation; Mitochondrion; Biochemistry; Pyruvate decarboxylation; Biology; Citric acid cycle; Pyruvate kinase; Drosophila melanogaster; Metabolism; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase complex; Cell biology; Enzyme; Glycolysis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005601858,0.0003144059,0.0001476807,0.0003912044,0.0001679656,0.0001996033,0.0001487009,0.0002578584,0.0008071916],"category_scores_gemma":[0.00006615496,0.0001092828,0.0002164838,0.0001835319,0.0001478661,0.0001523752,0.0001285866,0.0003699965,0.000157285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000278593,"about_ca_system_score_gemma":0.000122984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002321743,"about_ca_topic_score_gemma":0.003193377,"domain_scores_codex":[0.999931,0.000006653639,0.00001024243,0.00002584535,0.00001572646,0.00001057068],"domain_scores_gemma":[0.9999093,0.000009812356,0.00003547865,0.000007113699,0.00001083102,0.00002737768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006386507,0.000009596727,0.0008481975,0.00002787758,0.00000544057,0.00008713342,0.00001564092,0.00003948329,0.9983974,0.00003656137,0.00001389133,0.0004547735],"study_design_scores_gemma":[0.00002210761,0.0003316352,0.1110366,0.00001652363,0.00005204469,0.001148384,0.0001801592,0.001542486,0.8832568,0.0001028162,0.002291446,0.00001900923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996226,0.000556738,0.000912183,0.00003505863,0.000006971201,0.00001975318,0.001728451,0.0000245314,0.0004903937],"genre_scores_gemma":[0.9936569,0.000566064,0.001882414,0.00004554449,0.000003358459,0.00003133877,0.002058836,0.00002933437,0.001726102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002321743,"threshold_uncertainty_score":0.004616439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01560800983253576,"score_gpt":0.2348785438761919,"score_spread":0.2192705340436562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}