{"id":"W3083111306","doi":"10.3390/metabo10090363","title":"Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in Drosophila melanogaster","year":2020,"lang":"en","type":"article","venue":"Metabolites","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; New Brunswick Innovation Foundation; Fondation de la recherche en santé du Nouveau-Brunswick; Université de Moncton","keywords":"Oxidative phosphorylation; Mitochondrion; Biochemistry; Pyruvate decarboxylation; Biology; Citric acid cycle; Pyruvate kinase; Drosophila melanogaster; Metabolism; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase complex; Cell biology; Enzyme; Glycolysis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007634089,0.0001201636,0.0002417495,0.00005453384,0.00002569718,0.00001378996,0.00008796025,0.000104935,0.00005604807],"category_scores_gemma":[0.0001764235,0.0001072801,0.00004800512,0.0001522276,0.0001467361,0.000008192766,0.00005190641,0.00006132892,0.000004401552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001082574,"about_ca_system_score_gemma":0.00003816502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009403002,"about_ca_topic_score_gemma":0.00000712051,"domain_scores_codex":[0.9990978,0.0001156701,0.0002613825,0.000293814,0.0000827211,0.0001486195],"domain_scores_gemma":[0.9996431,0.0000106004,0.00009382073,0.0001267166,0.00005249092,0.00007322907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001091267,0.00001387689,0.01660106,0.00001375251,0.000009693043,0.000001599778,0.0002421578,0.000003944437,0.9812891,0.001234453,0.00002923098,0.0004519743],"study_design_scores_gemma":[0.0007090064,0.0001080372,0.0156782,0.00000464589,0.00002854544,0.000007357333,0.00005497156,0.00002175247,0.9212999,0.00009103974,0.06186278,0.0001338184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950293,0.002372584,0.001209641,0.0005451446,0.0003475672,0.0001635982,0.00009176746,0.000007505394,0.0002328913],"genre_scores_gemma":[0.9970767,0.0004866575,0.0009126837,0.0007711576,0.0003807644,0.00001710504,0.0001452595,0.00001232033,0.0001973295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06183355,"threshold_uncertainty_score":0.4374755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01560800983253576,"score_gpt":0.2348785438761919,"score_spread":0.2192705340436562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}