{"id":"W3083114613","doi":"10.1158/1538-7445.am2020-1112","title":"Abstract 1112: Feasibility of real-time personalized patient-derived Tumorgraft® models for guiding systemic treatment in recurrent and/or metastatic head and neck cancer patients","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; London Health Sciences Centre","funders":"","keywords":"Medicine; Regimen; Drug response; Internal medicine; Head and neck cancer; Oncology; Progressive disease; Cancer; Biopsy; Head and neck; Basal cell; Disease; Surgery; Drug; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003638482,0.0001932766,0.0002109335,0.00009678001,0.00008792665,0.0004270143,0.0001694783,0.0002590044,0.001283703],"category_scores_gemma":[0.0001639792,0.0001073123,0.0001711794,0.0001020179,0.0001301127,0.0001770025,0.0001863569,0.0004222542,0.000312945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002761182,"about_ca_system_score_gemma":0.0002389173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007500005,"about_ca_topic_score_gemma":0.0007031226,"domain_scores_codex":[0.9998817,0.00002618256,0.000005459618,0.00002835787,0.00004182533,0.00001639992],"domain_scores_gemma":[0.9999099,0.00002211783,0.00001810505,0.00002078012,0.00001128366,0.0000178306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006359408,0.0003478253,0.003745474,0.00005772465,0.00001884384,0.00008979474,0.00005318356,0.002938496,0.9823595,0.0002289724,0.0005784939,0.008945818],"study_design_scores_gemma":[0.0001763781,0.006929242,0.01767933,0.00001456626,0.00008788258,0.0007256476,0.00007405396,0.03473686,0.9327277,0.0001136617,0.006719139,0.00001559536],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9906353,0.0004698723,0.006986833,0.00006262353,0.00002978096,0.0001094715,0.0004116451,0.0001416017,0.001152825],"genre_scores_gemma":[0.991936,0.0002412443,0.005845062,0.00003277674,0.000005215997,0.00008090641,0.0007211674,0.00001915451,0.001118496],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001283703,"threshold_uncertainty_score":0.004294395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1684623423104833,"score_gpt":0.4239863900308204,"score_spread":0.2555240477203372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}