{"id":"W3083124691","doi":"10.1158/1538-7445.am2020-6710","title":"Abstract 6710: AVID200, a first-in-class selective TGF-beta 1 and -beta 3 inhibitor, sensitizes tumors to immune checkpoint blockade therapies","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"In vivo; Cancer research; TGF beta signaling pathway; Cancer immunotherapy; Immunotherapy; Blockade; Medicine; Transforming growth factor beta; Ectodomain; Immune checkpoint; Immune system; Tumor microenvironment; Cancer; Pharmacology; Immunology; Biology; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008574255,0.0003276836,0.0001943295,0.000213417,0.00007835931,0.0002345351,0.0002610148,0.0003604438,0.004542147],"category_scores_gemma":[0.00005862234,0.0001021348,0.000144628,0.0001264882,0.0001021831,0.0001293338,0.0001141754,0.0005706648,0.001076817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002895926,"about_ca_system_score_gemma":0.0002596244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008586789,"about_ca_topic_score_gemma":0.00138583,"domain_scores_codex":[0.9999496,0.00000559967,0.000002673457,0.000007046504,0.00001609353,0.00001905285],"domain_scores_gemma":[0.9999727,0.000005198424,0.000005262115,0.000002233475,0.000003841026,0.00001086039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00133182,0.0004088338,0.0004926383,0.0001342544,0.00002128872,0.0002220367,0.00001894162,0.0004229909,0.9655913,0.0002683136,0.002879733,0.02820797],"study_design_scores_gemma":[0.0005852395,0.005256232,0.005303285,0.00002335517,0.0000575441,0.001908795,0.00001907752,0.002803398,0.9617894,0.0001193451,0.0221219,0.00001253956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9738858,0.006696598,0.003581844,0.0005216937,0.0001763916,0.00008830889,0.001060042,0.0004124838,0.01357693],"genre_scores_gemma":[0.9786991,0.002777403,0.002929678,0.0003700668,0.00006355276,0.00004714209,0.002088977,0.00004649659,0.0129775],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.004542147,"threshold_uncertainty_score":0.01519495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06202703810496706,"score_gpt":0.3577934308272735,"score_spread":0.2957663927223064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}