{"id":"W3083171017","doi":"10.1158/1538-7445.am2020-685","title":"Abstract 685: Sortilin receptor-mediated novel cancer therapy: A targeted approach to inhibit vasculogenic mimicry in ovarian and breast cancers","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"","keywords":"Vasculogenic mimicry; Ovarian cancer; Cancer research; Doxorubicin; Matrigel; Triple-negative breast cancer; Cancer; Breast cancer; Docetaxel; Cancer cell; Cancer stem cell; Medicine; Biology; Chemistry; Internal medicine; Metastasis; Chemotherapy; Angiogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134474,0.0002871956,0.0002300763,0.0002024378,0.00008521809,0.0002144039,0.0001831187,0.0003255137,0.001900191],"category_scores_gemma":[0.00003843136,0.00007438827,0.0002136043,0.0001408831,0.0001130865,0.0001541657,0.0001313992,0.0004233121,0.000453864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003065355,"about_ca_system_score_gemma":0.0002010149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004561241,"about_ca_topic_score_gemma":0.0006420158,"domain_scores_codex":[0.9999555,0.000007876284,0.00000294917,0.000006984472,0.00001193417,0.0000146631],"domain_scores_gemma":[0.9999807,0.000002663242,0.000005201,0.00000157975,0.000003636039,0.000006187016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004196884,0.0001706271,0.000163758,0.0002315945,0.00002561928,0.0001274609,0.00002423545,0.0003046965,0.9796721,0.0007245233,0.0008382608,0.01729752],"study_design_scores_gemma":[0.0002514345,0.001805607,0.002187009,0.00001898118,0.00007402382,0.0007086674,0.00001601006,0.001702867,0.9749254,0.0001162163,0.01818436,0.000009476621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9595336,0.01720973,0.01068067,0.001055471,0.0002523529,0.0002865927,0.0007020294,0.0003474446,0.009932146],"genre_scores_gemma":[0.9795681,0.006818225,0.005236124,0.0003193209,0.00004435652,0.0001108278,0.0004557441,0.00002109618,0.00742606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001900191,"threshold_uncertainty_score":0.006356776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05204581272193721,"score_gpt":0.3277477227346361,"score_spread":0.2757019100126989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}