{"id":"W3083171877","doi":"10.1158/1538-7445.am2020-5465","title":"Abstract 5465: HRDetect as a predictive score of platinum response in advanced PDAC","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University Health Centre; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"","keywords":"PALB2; CHEK2; Medicine; Indel; Internal medicine; Oncology; Germline; Population; Germline mutation; Mutation; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006226487,0.0002044556,0.0002614709,0.0005721257,0.0001612599,0.0004824253,0.0002063855,0.0003302752,0.0035561],"category_scores_gemma":[0.001479948,0.00009949426,0.0002213951,0.0005206346,0.0001868884,0.0002518239,0.0003841172,0.0003947651,0.0005887541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001659362,"about_ca_system_score_gemma":0.0001378464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000437131,"about_ca_topic_score_gemma":0.0006095614,"domain_scores_codex":[0.9997991,0.00006749325,0.00002648451,0.00004213887,0.00003739447,0.00002744242],"domain_scores_gemma":[0.9985985,0.0004592648,0.0004791146,0.00005828934,0.00009581562,0.0003089888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009063134,0.00003078409,0.9942689,0.00001199203,0.00002309011,0.00003909739,0.000006932246,0.0001543154,0.0005068365,0.00001098856,0.0002716621,0.0037691],"study_design_scores_gemma":[0.00003949296,0.0003214703,0.997378,0.000006624781,0.00004135552,0.0002745646,0.00002463547,0.001046702,0.000445032,0.00004356212,0.0003739211,0.00000472432],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998008,0.0001945945,0.0001494869,0.00005938419,0.000009796808,0.00001316106,0.000753116,0.00001168709,0.0008008415],"genre_scores_gemma":[0.9988573,0.00004280176,0.0001676834,0.00001749722,0.00001518626,0.000008811247,0.0006585438,0.00000238245,0.0002298216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0035561,"threshold_uncertainty_score":0.01189637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04655848575234597,"score_gpt":0.3757191651520273,"score_spread":0.3291606793996814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}