{"id":"W3083172821","doi":"10.1158/1538-7445.am2020-5246","title":"Abstract 5246: Disulfiram anticancer metabolite, dithiocarb-copper complex, demonstrates anti-neoplastic activity against hypermutated colorectal cancers","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Colorectal cancer; Irinotecan; Cancer research; Cancer; KRAS; Medicine; In vivo; Microsatellite instability; Apoptosis; Cancer cell; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006271635,0.0002865321,0.0002058056,0.0002426554,0.00009955035,0.0001171619,0.0001552223,0.0002036084,0.002278363],"category_scores_gemma":[0.00007350971,0.00008912562,0.0001384265,0.0001474738,0.0001067064,0.00009093636,0.00009159561,0.0002461028,0.0003015665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001263192,"about_ca_system_score_gemma":0.0001471617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006806775,"about_ca_topic_score_gemma":0.0007927064,"domain_scores_codex":[0.9999608,0.000006448548,0.000003449977,0.00000732554,0.00001342836,0.000008530888],"domain_scores_gemma":[0.9999614,0.000005573619,0.000008771853,0.000004040283,0.000007023186,0.00001318418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003315743,0.00009744259,0.0001475371,0.0001640496,0.00001450796,0.00007736477,0.00001180268,0.00008633792,0.9945058,0.00005337454,0.0003368626,0.004173359],"study_design_scores_gemma":[0.0001060902,0.002700476,0.002471949,0.000009892161,0.00003617226,0.0003419331,0.000008841302,0.0005112551,0.9891168,0.00001736032,0.004674079,0.000005018805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868772,0.006345064,0.001188856,0.0001952979,0.00008053388,0.00009061967,0.0005482989,0.0002094086,0.004464759],"genre_scores_gemma":[0.9913394,0.002433121,0.001594434,0.00008176485,0.00003008463,0.00002837971,0.0008891147,0.00001574518,0.003587831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002278363,"threshold_uncertainty_score":0.007621884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05821167981273766,"score_gpt":0.3554162833065271,"score_spread":0.2972046034937895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}