{"id":"W3083196805","doi":"10.1016/j.lungcan.2020.09.002","title":"Whole exome sequencing reveals BAP1 somatic abnormalities in mesothelioma in situ","year":2020,"lang":"en","type":"article","venue":"Lung Cancer","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"BAP1; Mesothelioma; Peritoneal mesothelioma; Germline mutation; Exome sequencing; Cancer research; Copy number analysis; Somatic cell; Germline; Fluorescence in situ hybridization; Exome; Biology; Pathology; Copy-number variation; Mutation; Medicine; Genetics; Gene; Chromosome; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388801,0.0003499977,0.0001741387,0.0007942924,0.0004450487,0.000664976,0.0002634148,0.0009490566,0.00414348],"category_scores_gemma":[0.0006037991,0.000190807,0.0003607446,0.0004551434,0.0002450508,0.0002000922,0.00041414,0.0004178994,0.0006907287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588839,"about_ca_system_score_gemma":0.0001436423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001273212,"about_ca_topic_score_gemma":0.002776589,"domain_scores_codex":[0.9998068,0.000009587278,0.00001510386,0.00006952126,0.000065427,0.00003351287],"domain_scores_gemma":[0.9997804,0.00008462567,0.0000463859,0.00002756224,0.00002718445,0.00003390058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008019956,0.00008911843,0.1204194,0.0001834114,0.000250332,0.01734549,0.0006000357,0.0009254615,0.8242927,0.0004470031,0.001736378,0.0329085],"study_design_scores_gemma":[0.00006412885,0.0003429617,0.7741779,0.00007110449,0.0004317276,0.05853909,0.001114795,0.002966643,0.1435315,0.001457197,0.01726814,0.00003486043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993786,0.00048582,0.0007142127,0.0003406797,0.0000284472,0.0000110668,0.002277919,0.00007758656,0.002278314],"genre_scores_gemma":[0.9957643,0.0003069086,0.0006017677,0.0001165848,0.00001226755,0.000007223024,0.001207115,0.00001728637,0.00196659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00414348,"threshold_uncertainty_score":0.0138613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211779465801011,"score_gpt":0.2903933627755822,"score_spread":0.2682755681175721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}