{"id":"W3083202954","doi":"10.1158/1538-7445.am2020-1194","title":"Abstract 1194: Cross-cancer GWAS meta-analysis of more than 370,000 cases and 530,000 controls identifies multiple novel cancer risk regions","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Genome-wide association study; Cancer; Meta-analysis; Colorectal cancer; Prostate cancer; Breast cancer; Oncology; Biology; Medicine; Internal medicine; Genetics; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01524667,0.002693854,0.006437446,0.00384897,0.001081586,0.003437875,0.001959507,0.001703718,0.004939598],"category_scores_gemma":[0.02414799,0.001439355,0.03258124,0.006117508,0.0006242558,0.001262965,0.001506431,0.002605858,0.0006003198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009354536,"about_ca_system_score_gemma":0.001214097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009419074,"about_ca_topic_score_gemma":0.01112508,"domain_scores_codex":[0.9832187,0.009416936,0.002059972,0.003581204,0.001254174,0.000468992],"domain_scores_gemma":[0.9836426,0.009587708,0.001773506,0.003117934,0.001486142,0.0003920764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005278042,0.00004117072,0.1041756,0.004525971,0.8718686,0.0005270136,0.00007877455,0.002330181,0.002125889,0.0003744577,0.00225847,0.006415969],"study_design_scores_gemma":[0.0013299,0.0003177481,0.0641014,0.0006814869,0.923274,0.0004935313,0.00008142099,0.004128018,0.00118719,0.001380242,0.002971007,0.00005395309],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4312597,0.4836378,0.05444698,0.003520409,0.002534352,0.0006502091,0.01897612,0.001364018,0.00361048],"genre_scores_gemma":[0.9748569,0.01239692,0.006976365,0.0007456874,0.0003569276,0.0003155462,0.003268854,0.0001966795,0.0008862803],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01524667,"threshold_uncertainty_score":0.0806331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2032077128479647,"score_gpt":0.455281033930309,"score_spread":0.2520733210823443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}