{"id":"W3083211751","doi":"10.1158/1538-7445.am2020-3438","title":"Abstract 3438: Hypoxia inhibits BMP4-induced astrocytic differentiation in glioma stem cells","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Hypoxia (environmental); Biology; Stem cell; Cellular differentiation; Cell biology; Cancer research; Neural stem cell; Glial fibrillary acidic protein; Epigenetics; Immunology; Chemistry; Genetics; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008260241,0.0004145111,0.0003540004,0.0002214373,0.0001337721,0.0001578173,0.0002817642,0.0002210011,0.003435075],"category_scores_gemma":[0.00007737339,0.0001177909,0.0002279839,0.0001832813,0.0001415539,0.00009375743,0.0001803703,0.0004402531,0.0008023917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916276,"about_ca_system_score_gemma":0.0002984307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298249,"about_ca_topic_score_gemma":0.001561535,"domain_scores_codex":[0.99991,0.00001798104,0.00001092436,0.00001191914,0.00002550187,0.00002366719],"domain_scores_gemma":[0.9999527,0.000008217164,0.000009870927,0.000006735157,0.000005691239,0.00001675127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000299545,0.00008795888,0.0001180081,0.0000775587,0.00000724949,0.00004899545,0.00001205766,0.00008055804,0.9972593,0.00005450964,0.0001848422,0.001769383],"study_design_scores_gemma":[0.00006240614,0.0008808775,0.002810294,0.000007862223,0.00001255656,0.0001419242,0.00001578595,0.000694097,0.9918677,0.00002859727,0.003474565,0.00000337837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924161,0.002150113,0.001093818,0.0001838356,0.00005299643,0.00006529511,0.001132083,0.0001459037,0.002759816],"genre_scores_gemma":[0.988687,0.001353389,0.001919292,0.00008732922,0.00002595461,0.000103524,0.002733806,0.00002953942,0.00506015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003435075,"threshold_uncertainty_score":0.01149148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06586998332408771,"score_gpt":0.3397765157149908,"score_spread":0.2739065323909031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}