{"id":"W3083212569","doi":"10.1101/2020.09.05.284349","title":"<i>CASCADES</i> , a novel <i>SOX2</i> super-enhancer associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma multiforme","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; McGill University; University of Calgary; Alberta Children's Hospital; Montreal Neurological Institute and Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"SOX2; Cancer research; Epigenetics; Cancer stem cell; Biology; Stem cell; Regulator; Carcinogenesis; Gene knockdown; Tumor initiation; Glioma; Cancer; Long non-coding RNA; Transcription factor; Cell biology; Genetics; RNA; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116061,0.0002413497,0.0001460553,0.0001636067,0.0001759229,0.0002341595,0.0001083501,0.0001830729,0.002034271],"category_scores_gemma":[0.00008891603,0.0000960665,0.0002492145,0.0001069198,0.0001714476,0.000153082,0.0001969836,0.0002919841,0.0005601122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515348,"about_ca_system_score_gemma":0.0002259726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034765,"about_ca_topic_score_gemma":0.001489789,"domain_scores_codex":[0.9999185,0.000006497331,0.000004358471,0.00002622826,0.00002900569,0.0000154823],"domain_scores_gemma":[0.9999534,0.000006018005,0.0000162473,0.000004288758,0.000006033751,0.00001395597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004275608,0.000007122942,0.0006408225,0.00002753578,0.000002952556,0.00007407369,0.000009949087,0.00008937976,0.9970978,0.0001724898,0.0002751539,0.001559876],"study_design_scores_gemma":[0.00003250664,0.0001241542,0.02624046,0.00001123341,0.00001690615,0.0005936441,0.00003800766,0.004468201,0.9588208,0.000306075,0.009336946,0.00001111768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741008,0.002477038,0.0120472,0.0004589144,0.0001670064,0.00005689144,0.002632105,0.0007899288,0.007270172],"genre_scores_gemma":[0.9828028,0.0009537476,0.005671954,0.0001743654,0.00003500536,0.00002608075,0.002635973,0.0001290013,0.007571113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002034271,"threshold_uncertainty_score":0.00680536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145081691215579,"score_gpt":0.2335123941238857,"score_spread":0.2190042250023278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}